SMAD7 Rabbit pAb
Datasheet
Catalog Number:
E2516396Amount:
100ulPrice:
225$Swiss-Prot No.:
O15105Altername:
SMAD7Storage/Stability:
Store at -20°C. Avoid freeze / thaw cycles.Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human SMAD7 (NP_005895.1).Purification:
Affinity purifiedReactivity:
Human,Mouse,RatOther Names:
CRCS3; MADH7; MADH8Cellular localization:
Cytoplasm, NucleusRelevance:
Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.Source:
RabbitAntibody type:
Polyclonal antibodyIsotype:
Rabbit IgGMolecular Weight:
23kDa/46kDaPreservative:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Recommended Dilutions:
WB 1:500 - 1:2000; IHC 1:50 - 1:200(Optimal dilutions should be determined by the end user)
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Catalog Number
- Amount:100ul
- Price:225$
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