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ATG7 Rabbit pAb
Datasheet   

  • Catalog Number:

    E2511287

  • Amount:

    100ul

  • Price:

    225$

  • Swiss-Prot No.:

    O95352

  • Altername:

    ATG7

  • Storage/Stability:

    Store at -20°C. Avoid freeze / thaw cycles.

  • Immunogen:

    Recombinant fusion protein containing a sequence corresponding to amino acids 500-676 of human ATG7 (NP_001129503.2).

  • Purification:

    Affinity purified

  • Reactivity:

    Human

  • Other Names:

    GSA7; APG7L; APG7-LIKE

  • Cellular localization:

    Cytoplasm

  • Relevance:

    E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis, the prevention of axonal degeneration, the maintenance of hematopoietic stem cells, the formation of Paneth cell granules, as well as in adipose differentiation.

  • Source:

    Rabbit

  • Antibody type:

    Polyclonal antibody

  • Isotype:

    Rabbit IgG

  • Molecular Weight:

    68kDa/75kDa/77kDa

  • Preservative:

    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

  • Recommended Dilutions:

    IHC 1:50 - 1:100(Optimal dilutions should be determined by the end user)

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  • Amount:100ul
  • Price:225.00$

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