TMEM173 Rabbit pAb
Datasheet
Catalog Number:
E2503575Amount:
100ulPrice:
225$Swiss-Prot No.:
Q86WV6Altername:
TMEM173Storage/Stability:
Store at -20°C. Avoid freeze / thaw cycles.Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 170-379 of human TMEM173 (NP_938023.1).Purification:
Affinity purifiedReactivity:
Human,MouseOther Names:
ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; STING-betaCellular localization:
Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Mitochondrion outer membraneRelevance:
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2',3' phosphodiester linkage-specific ligand recognition. Can bind both 2'-3' linked cGAMP and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP (PubMed:26300263).Source:
RabbitAntibody type:
Polyclonal antibodyIsotype:
Rabbit IgGMolecular Weight:
39kDaPreservative:
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.Recommended Dilutions:
WB 1:500 - 1:2000; IHC 1:50 - 1:100(Optimal dilutions should be determined by the end user)
Related Products
Catalog Number
- Amount:100ul
- Price:225$
Contact us
Categories by research area
Categories by product type
- Antibodies
- Tag antibodies
- Internal control antibodies
- Pathological (Immunohistochemistry, IHC) antibodies
- Cell Signal Transduction Research Antibodies
- Secondary Antibody
- Antibody Sampler Kits
- Recombinant Proteins
- Fluorescence Reagents
- Signal Inhibitors and Activators
- Transfection Reagent
- Cell biology kits