4E-BP1 Mouse mAb | EnoGene Biotech Co. Ltd

4E-BP1 Mouse mAb
Datasheet

Catalog Number:
E2220122
Amount:
100ul
Price:
225$
Swiss-Prot No.:
Q13541
Altername:
4E-BP1
Storage/Stability:
Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Immunogen:
Purified recombinant fragment of 4EBP1 expressed in E. Coli.
Purification:
Ascitic fluid
Reactivity:
Human
Other Names:
BP-1; 4EBP1; 4E-BP1; PHAS-I; MGC4316; EIF4EBP1
Background:
4E-BP1(eukaryotic translation Initiation Factor 4E Binding Protein 1),also called ELF4EBP1/BP-1/PHAS-I ,which is located on chromosome 8p12, with 118-amino acid protein (about 13kDa). Binding of eIF4EBP1 to eIF4E is reversible and is dependent on the phosphorylation status of eIF4EBP1. Non phosphorylated eIF4EBP1 will bind strongly to eIF4E while(24kDa), the phosphorylated form will not. Akt, TOR, MAP kinase, S6 kinase, and Cdc2 are known kinases capable of inactivating eIF4EBP1 binding to eIF4E by phosphorylating either threonines 35, 45, 69 or serine 64. Although, not all phosphorylation events equally block the eIF4EBP1-eIF4E interaction.
Gene ID:
1978
Source:
Mouse
Antibody type:
Monclonal antibody
Isotype:
Mouse IgG1
Preservative:
Ascitic fluid containing 0.03% sodium azide.
Recommended Dilutions:
WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: N/A; FCM: N/A; Elisa: 1/10000
Clone Number:
11G12C11

4E-BP1 Mouse mAb
Datasheet