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2019-nCoV & Monkeypox

Recombinant 2019-nCoV S1 Protein RBD-SD1 (C-6His)

E21-RA42-1DatasheetCOAMSDS
QHD43416.1
Human Cells
Price on request
Quantity

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

Specificty Sensitivity

Specificity/SensitivityVirus

Product Information

Molecular WeightMol Mass: 31.4kDa AP Mol Mass: 35-43kDa, reducing conditions
PurityGreater than 95% as determined by reducing SDS-PAGE.
DescriptionRecombinant 2019-nCoV S Protein RBD-SD1 is produced by Mammalian expression system and the target gene encoding Arg319-Ser591 is expressed with a 6His tag at the C-terminus..
FormulationSupplied as a 0.2 μM filtered solution of PBS, pH 7.4
FormName:Recombinant 2019-nCoV S Protein RBD-SD1 (C-6His)
Other Names2019-nCov RBD Protein; 2019-nCoV Spike RBD Protein
Storage/StabilityReconstituted protein solution should be stored at ≤ -20°C.
PurificationAffinity purification chromatography.
Immunogen, calibrator or standard.
BackgroundProtein S (PROS1) is glycoprotein and expressed in many cell types supporting its reported involvement in multiple biological processes that include coagulation, apoptosis, cancer development and progression, and the innate immune response. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2, DPP4, CEACAM etc.. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
SDS-PAGE:
SEC-HPLC:
Immobilized 2019-nCoV S Protein RBD-SD1-His (Cat# E21-RA42-1) at 5μg/ml (100 μl/well) can bind Human ACE-2-Fc(Cat# E21-O5Y-2).The ED50 of Recombinant Human ACE-2-Fc(Cat# E21-O5Y-2) is 76 ng/ml.
Immobilized 2019-nCoV S Protein RBD-SD1-His (Cat# E21-RA42-1) at 5μg/ml (100 μl/well) can bind Human ACE-2-Fc(Cat# E21-O5Y-2).The ED50 of Recombinant Human ACE-2-Fc(Cat# E21-O5Y-2) is 76 ng/ml.
Immobilized 2019-nCoV S Protein RBD-SD1-His (Cat# E21-RA42-1) at 5 μg/ml (100 μl/well) can bind Anti-2019-nCoV S1 mAb (Cat# E21- C025-1).The ED50 of Anti-2019-nCoV S1 mAb (Cat# E21-C025-1) is 2.2 ng/ml.
Immobilized 2019-nCoV S Protein RBD-SD1-His (Cat# E21-RA42-1) at 5 μg/ml (100 μl/well) can bind Anti-2019-nCoV S1 mAb (Cat# E21- C025-1).The ED50 of Anti-2019-nCoV S1 mAb (Cat# E21-C025-1) is 2.2 ng/ml.
Batch stability was confirmed by binding ability with For Research
Batch stability was confirmed by binding ability with For Research
ACE-2(Cat# E21-O5Y-2) or Anti-2019-nCoV-S1 mAb Use Only
ACE-2(Cat# E21-O5Y-2) or Anti-2019-nCoV-S1 mAb Use Only
Freeze-thaw stability was tested by repeated freeze-thaw bioactivity had no significant differences after
Freeze-thaw stability was tested by repeated freeze-thaw bioactivity had no significant differences after
📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E21-RA42-1-Conjugate. Price: $485 / Size: 100μl.

E21-RA42-1-FITC$485 / 100μlE21-RA42-1-Biotin$485 / 100μlE21-RA42-1-HRP$485 / 100μlE21-RA42-1-AP$485 / 100μlE21-RA42-1-AF350$485 / 100μlE21-RA42-1-AF405M$485 / 100μlE21-RA42-1-AF488$485 / 100μlE21-RA42-1-AF514$485 / 100μlE21-RA42-1-AF532$485 / 100μlE21-RA42-1-AF555$485 / 100μlE21-RA42-1-AF568$485 / 100μlE21-RA42-1-AF405S$485 / 100μlE21-RA42-1-AF405L$485 / 100μlE21-RA42-1-AF546$485 / 100μlE21-RA42-1-AF594$485 / 100μlE21-RA42-1-AF610$485 / 100μlE21-RA42-1-AF635$485 / 100μlE21-RA42-1-AF647$485 / 100μlE21-RA42-1-AF680$485 / 100μlE21-RA42-1-AF700$485 / 100μlE21-RA42-1-AF750$485 / 100μlE21-RA42-1-AF790$485 / 100μlE21-RA42-1-APC$485 / 100μlE21-RA42-1-PE$485 / 100μlE21-RA42-1-Cy3$485 / 100μlE21-RA42-1-Cy5$485 / 100μlE21-RA42-1-Cy5.5$485 / 100μlE21-RA42-1-Cy7$485 / 100μlE21-RA42-1-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.

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