Specificty Sensitivity
Specificity/SensitivityVirus
Product Information
Molecular WeightMol Mass: 49.4kDa AP Mol Mass: 50-60kDa, reducing conditions
PurityGreater than 95% as determined by reducing SDS-PAGE.
DescriptionRecombinant 2019-nCoV Nucleocapsid Protein is produced by our E.coli expression system and the target gene encoding Met1-Ala419 is expressed with a 6His tag at the N-terminus.
FormulationSupplied as a 0.2 μM filtered solution of PBS, pH 7.4
FormName:Recombinant 2019-nCoV Nucleocapsid Protein
Other Names2019-nCoV coronavirus NP Protein; 2019-nCoV np Protein; 2019-nCoV novel coronavirus Nucleoprotein Protein
Storage/StabilityReconstituted protein solution should be stored at ≤ -20°C.
PurificationAffinity purification chromatography.
Immunogen, calibrator or standard.
BackgroundCoronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. N protein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. Plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.