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2019-nCoV & Monkeypox
Recombinant Human ACE-2 (C-mFc)
Price on request
Specification
Quantity
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Specificty Sensitivity
Specificity/SensitivityHuman
Product Information
PurityGreater than 95% as determined by reducing SDS-PAGE. Endotoxin: Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
DescriptionRecombinant Human Angiotensin-Converting Enzyme 2 is produced by Mammalian expression system and the target gene encoding Gln18-Ser740 is expressed with a Fc tag at the C-terminus.
FormulationSupplied as a 0.2 μm filtered solution of 20mM Tris，300mM Nacl,1mM Zncl2,10% Glycerol，pH7.4.
FormName:Recombinant Human ACE-2 (C-mFc), Accession #: Q9BYF1
Other NamesAngiotensin-Converting Enzyme 2; ACE-Related Carboxypeptidase; Angiotensin-Converting Enzyme Homolog; ACEH; Metalloprotease MPROT15; ACE2
Storage/StabilityStore at < -20°C, stable for 6 months after receipt.
BackgroundAngiotensin-Converting Enzyme 2 (ACE-2) is an integral membrane protein and a zinc metalloprotease of the ACE family, the ACE family includes somatic and germinal ACE. ACE-2 cleaves angiotensins I and II as a carboxypeptidase, ACE-2 converts angiotensin I to angiotensin 1-9, and angiotensin II to angiotensin 1-7. ACE-2 is also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. ACE-2 can be high expressed in testis, kidney and heart, in colon, small intestine and ovary at moderate levels. Captopril and lisinopril as the classical ACE inhibitor don’t inhibit ACE-2 activity. ACE-2 may play an important role in regulating the heart function.
Bioactivity of Recombinant Human ACE-2 (C-mFc). Immobilized 2019-nCoV S1 Protein-Fc (Cat# E21-RA37-1) at 10μg/ml (100 μl/well) can bind Human ACE-2-mFc(Cat#E21-O6A-2). The ED50 of Recombinant Human ACE-2-mFc (Cat#E21-O6A-2) is 0.58 ug/ml.
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