Interleukin-35/IL-35
Datasheet
Catalog Number:
E21-M89Amount:
10ugPrice:
225$Altername:
Interleukin 35; IL35; hIL35Storage/Stability:
Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.Background:
Interleukin-35 is a newest and potent suppressive cytokine of the IL-12 family. Unlike other members of the IL-12 family which are produced mainly by antigen-presenting cells (APCs), IL-35 has been identified as a potentially immunosuppressive cytokine primarily produced by regulatory T (Treg) cells, and to a lesser extent by activated dendritic cells and macrophages. IL-35 is composed of the IL-12 p35 subunit and the IL-27 Epstein–Barr virus-induced protein 3 (EBI3) subunit. IL-35 plays an important role in many disease models and has been recently shown to have additional functions aside from inhibition of proliferation, including inducing its own expression in non-Treg cells.Species:
HumanReconstitution:
Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 μg/ml.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.Endotoxin:
Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.Purity:
Greater than 80% as determined by reducing SDS-PAGE.Description:
Recombinant Human Interleukin-35 is produced by our Mammalian expression system and the target gene encoding Arg21-Lys229&Arg23-Ser219 is expressed with a Fc tag at the C-terminus.Product State:
LyophilizedShip Description:
The product is shipped at ambient temperature.Formulation:
Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.Expression system:
Human cells
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Catalog Number
- Amount:10ug
- Price:225$
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