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Nrf2 protein
$275/ 20ug
QuantityTotal: $275
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Price275$
Storage/StabilityUp to 1 year when aliquoted and stored at -20 to -80 °C
Gene NameNFE2L2 NRF2Sequence:Amino acid: 11-130, with his-MBP tag
Backgrounddomain:Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.,function:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.,PTM:Phosphorylation of Ser-40 by PKC in response to oxidative stress dissociates NFE2L2 from its cytoplasmic inhibitor KEAP1, promoting its translocation into the nucleus.,similarity:Belongs to the bZIP family.,similarity:Belongs to the bZIP family. CNC subfamily.,similarity:Contains 1 bZIP domain.,subcellular location:Cytosolic under unstressed conditions, translocates into the nucleus upon induction by electrophilic agents.,subunit:Heterodimer. May bind DNA with an unknown protein. Interacts with KEAP1. Interacts via its leucine-zipper domain with the coiled-coil domain of PMF1.,tissue specificity:Widely expressed. Highest expression in adult muscle, kidney, lung, liver and in fetal muscle.,
Product Information
Formulation0.15 M Phosphate buffered saline, pH 7.4
Protein NameNrf2 protein
Other NameNFE2L2, NRF2, NFE2 like bZIP transcription factor 2, Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)
SequenceAmino acid: 11-130, with his-MBP tag.LPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQEQLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM
Human Gene Id4780
Human Swiss Prot NoQ16236
Mouse Swiss Prot NoQ60795
ConcentrationSDS-PAGE >90%
ExpressionE. coli
Vector and tagC-His tag
SolubilitySoluble
Functiontranscription, transcription, DNA-dependent, regulation of transcription, DNA-dependent, transcription from RNA polymerase II promoter, ER-nuclear signaling pathway, response to unfolded protein, positive regulation of biosynthetic process, response to organic substance, positive regulation of macromolecule biosynthetic process,positive regulation of macromolecule metabolic process, positive regulation of gene expression, endoplasmic reticulum unfolded protein response, positive regulation of cellular biosynthetic process, RNA biosynthetic process, cellular response to stress, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process.
Conjugated Antibody
This product is also available conjugated. Format: E20-80126-Conjugate. Price: $485 / Size: 100μl.
E20-80126-FITC$485 / 100μlE20-80126-Biotin$485 / 100μlE20-80126-HRP$485 / 100μlE20-80126-AP$485 / 100μlE20-80126-AF350$485 / 100μlE20-80126-AF405M$485 / 100μlE20-80126-AF488$485 / 100μlE20-80126-AF514$485 / 100μlE20-80126-AF532$485 / 100μlE20-80126-AF555$485 / 100μlE20-80126-AF568$485 / 100μlE20-80126-AF405S$485 / 100μlE20-80126-AF405L$485 / 100μlE20-80126-AF546$485 / 100μlE20-80126-AF594$485 / 100μlE20-80126-AF610$485 / 100μlE20-80126-AF635$485 / 100μlE20-80126-AF647$485 / 100μlE20-80126-AF680$485 / 100μlE20-80126-AF700$485 / 100μlE20-80126-AF750$485 / 100μlE20-80126-AF790$485 / 100μlE20-80126-APC$485 / 100μlE20-80126-PE$485 / 100μlE20-80126-Cy3$485 / 100μlE20-80126-Cy5$485 / 100μlE20-80126-Cy5.5$485 / 100μlE20-80126-Cy7$485 / 100μlE20-80126-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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