Product Information
Molecular Weight57226Da
Protein NameBone morphogenetic protein 6
Human Gene Id654
Human Swiss Prot NoP22004
Mouse Gene Id12161
Mouse Swiss Prot NoP20722
Rat Gene Id25644
Rat Swiss Prot NoQ04906
SpecificityBMP-6 Polyclonal Antibody detects endogenous levels of BMP-6 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBMP6; VGR; Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VG-1-R; VGR-1
Observed Band(KD)60
Functionfunction:Induces cartilage and bone formation.,online information:Bone morphogenetic protein 6 entry,similarity:Belongs to the TGF-beta family.,subunit:Interacts with SOSTDC1.,
Subcellular Locationextracellular region,extracellular space,cytoplasm,membrane-bounded vesicle,
ExpressionBone,PCR rescued clones,
Backgroundbone morphogenetic protein 6(BMP6) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Differential expression of this gene may be associated with progression of breast and prostate cancer. Mutations in this gene may be associated with iron overload in human patients. [provided by RefSeq, Jul 2016],