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Cell Signal Transduction Research Antibodies
BMP-15 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight45055Da
Protein NameBone morphogenetic protein 15
Human Gene Id9210
Human Swiss Prot NoO95972
Mouse Gene Id12155
Mouse Swiss Prot NoQ9Z0L4
SpecificityBMP-15 Polyclonal Antibody detects endogenous levels of BMP-15 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBMP15; GDF9B; Bone morphogenetic protein 15; BMP-15; Growth/differentiation factor 9B; GDF-9B
Observed Band(KD)45
Functiondisease:Defects in BMP15 are the cause of ovarian dysgenesis 2 (ODG2) [MIM:300510]; also called X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Hypergonadotropic ovarian failure is a heterogeneous disorder that, in the most severe forms, is a result of ovarian dysgenesis (OD) or ovarian defective development. OD accounts for about half of the cases of primary amenorrhea.,function:May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.,miscellaneous:The mature protein migrates in two distinct mature proteins, P16 (16KDa) and P17 (17KDa).,similarity:Belongs to the TGF-beta family.,subunit:Homodimer. But, in contrast to other members of this family, cannot be disulfide-linked.,
Subcellular Locationextracellular space,cytoplasm,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human BMP15. AA range:291-340
Gene NameBMP15
DilutionIHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundbone morphogenetic protein 15(BMP15) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate subunits of a disulfide-linked homodimer, or alternatively, a heterodimer, with the related protein, growth differentiation factor 9 (GDF9). This protein plays a role in oocyte maturation and follicular development, through activation of granulosa cells. Defects in this gene are the cause of ovarian dysgenesis and are associated with premature ovarian failure. [provided by RefSeq, Aug 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75650-Conjugate. Price: $485 / Size: 100μl.
E20-75650-FITC$485 / 100μlE20-75650-Biotin$485 / 100μlE20-75650-HRP$485 / 100μlE20-75650-AP$485 / 100μlE20-75650-AF350$485 / 100μlE20-75650-AF405M$485 / 100μlE20-75650-AF488$485 / 100μlE20-75650-AF514$485 / 100μlE20-75650-AF532$485 / 100μlE20-75650-AF555$485 / 100μlE20-75650-AF568$485 / 100μlE20-75650-AF405S$485 / 100μlE20-75650-AF405L$485 / 100μlE20-75650-AF546$485 / 100μlE20-75650-AF594$485 / 100μlE20-75650-AF610$485 / 100μlE20-75650-AF635$485 / 100μlE20-75650-AF647$485 / 100μlE20-75650-AF680$485 / 100μlE20-75650-AF700$485 / 100μlE20-75650-AF750$485 / 100μlE20-75650-AF790$485 / 100μlE20-75650-APC$485 / 100μlE20-75650-PE$485 / 100μlE20-75650-Cy3$485 / 100μlE20-75650-Cy5$485 / 100μlE20-75650-Cy5.5$485 / 100μlE20-75650-Cy7$485 / 100μlE20-75650-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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