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Cell Signal Transduction Research Antibodies
NTN Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight22405Da
Protein NameNeurturin
Human Gene Id4902
Human Swiss Prot NoQ99748
Mouse Gene Id18188
Mouse Swiss Prot NoP97463
SpecificityNTN Polyclonal Antibody detects endogenous levels of NTN protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNRTN; Neurturin
Observed Band(KD)22
Functiondisease:Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.,function:Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.,similarity:Belongs to the TGF-beta family. GDNF subfamily.,subunit:Homodimer; disulfide-linked.,
Subcellular Locationextracellular region,intracellular,axon,
ExpressionMelanoma,Peripheral blood lymphocyte,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human NRTN. AA range:111-160
Gene NameNRTN
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundneurturin(NRTN) Homo sapiens This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. The encoded preproprotein is proteolytically processed to generate the mature protein. This protein signals through the RET receptor tyrosine kinase and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq, Aug 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75649-Conjugate. Price: $485 / Size: 100μl.
E20-75649-FITC$485 / 100μlE20-75649-Biotin$485 / 100μlE20-75649-HRP$485 / 100μlE20-75649-AP$485 / 100μlE20-75649-AF350$485 / 100μlE20-75649-AF405M$485 / 100μlE20-75649-AF488$485 / 100μlE20-75649-AF514$485 / 100μlE20-75649-AF532$485 / 100μlE20-75649-AF555$485 / 100μlE20-75649-AF568$485 / 100μlE20-75649-AF405S$485 / 100μlE20-75649-AF405L$485 / 100μlE20-75649-AF546$485 / 100μlE20-75649-AF594$485 / 100μlE20-75649-AF610$485 / 100μlE20-75649-AF635$485 / 100μlE20-75649-AF647$485 / 100μlE20-75649-AF680$485 / 100μlE20-75649-AF700$485 / 100μlE20-75649-AF750$485 / 100μlE20-75649-AF790$485 / 100μlE20-75649-APC$485 / 100μlE20-75649-PE$485 / 100μlE20-75649-Cy3$485 / 100μlE20-75649-Cy5$485 / 100μlE20-75649-Cy5.5$485 / 100μlE20-75649-Cy7$485 / 100μlE20-75649-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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