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Cell Signal Transduction Research Antibodies
Ebi3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight25396Da
Protein NameInterleukin-27 subunit beta
Human Gene Id10148
Human Swiss Prot NoQ14213
Mouse Gene Id50498
Mouse Swiss Prot NoO35228
SpecificityEbi3 Polyclonal Antibody detects endogenous levels of Ebi3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameEBI3; IL27B; Interleukin-27 subunit beta; IL-27 subunit beta; IL-27B; Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein
Observed Band(KD)25
Functionfunction:Cytokine with pro- and anti-inflammatory properties, that can regulate T helper cell development, suppress T-cell proliferation, stimulate cytotoxic T cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.,induction:By EBV.,online information:Interleukin-27 entry,similarity:Belongs to the
Subcellular Locationextracellular region,extracellular space,plasma membrane,
ExpressionB-cell,Pancreas,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human EBI3. AA range:101-150
Gene NameEBI3
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
BackgroundEpstein-Barr virus induced 3(EBI3) Homo sapiens This gene was identified by its induced expression in B lymphocytes in response Epstein-Barr virus infection. It encodes a secreted glycoprotein belonging to the hematopoietin receptor family, and heterodimerizes with a 28 kDa protein to form interleukin 27 (IL-27). IL-27 regulates T cell and inflammatory responses, in part by activating the Jak/STAT pathway of CD4+ T cells. [provided by RefSeq, Sep 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75645-Conjugate. Price: $485 / Size: 100μl.
E20-75645-FITC$485 / 100μlE20-75645-Biotin$485 / 100μlE20-75645-HRP$485 / 100μlE20-75645-AP$485 / 100μlE20-75645-AF350$485 / 100μlE20-75645-AF405M$485 / 100μlE20-75645-AF488$485 / 100μlE20-75645-AF514$485 / 100μlE20-75645-AF532$485 / 100μlE20-75645-AF555$485 / 100μlE20-75645-AF568$485 / 100μlE20-75645-AF405S$485 / 100μlE20-75645-AF405L$485 / 100μlE20-75645-AF546$485 / 100μlE20-75645-AF594$485 / 100μlE20-75645-AF610$485 / 100μlE20-75645-AF635$485 / 100μlE20-75645-AF647$485 / 100μlE20-75645-AF680$485 / 100μlE20-75645-AF700$485 / 100μlE20-75645-AF750$485 / 100μlE20-75645-AF790$485 / 100μlE20-75645-APC$485 / 100μlE20-75645-PE$485 / 100μlE20-75645-Cy3$485 / 100μlE20-75645-Cy5$485 / 100μlE20-75645-Cy5.5$485 / 100μlE20-75645-Cy7$485 / 100μlE20-75645-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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