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Cell Signal Transduction Research Antibodies
CD305 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight31412Da
Protein NameLeukocyte-associated immunoglobulin-like receptor 1
Human Gene Id3903
Human Swiss Prot NoQ6GTX8
Mouse Gene Id52855
Mouse Swiss Prot NoQ8BG84
Rat Gene Id574531
Rat Swiss Prot NoP0C1X9
SpecificityCD305 Polyclonal Antibody detects endogenous levels of CD305 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameLAIR1; CD305; Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; CD305
Observed Band(KD)32
Functiondevelopmental stage:Complete loss of expression when naive B-cells proliferates and differentiates into Ig-producing plasma cells under in vitro stimulation.,domain:ITIM (immunoreceptor tyrosine-based inhibitor motif) motif is a cytoplasmic motif present in 2 copies in the intracellular part of LAIR1. When phosphorylated, ITIM motif can bind the SH2 domain of several SH2-containing phosphatases, leading to down-regulation of cell activation.,function:Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modul
Subcellular Locationplasma membrane,integral component of membrane,extracellular exosome,
ExpressionPancreas,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human LAIR1. AA range:21-70
Gene NameLAIR1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundleukocyte associated immunoglobulin like receptor 1(LAIR1) Homo sapiens The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75634-Conjugate. Price: $485 / Size: 100μl.
E20-75634-FITC$485 / 100μlE20-75634-Biotin$485 / 100μlE20-75634-HRP$485 / 100μlE20-75634-AP$485 / 100μlE20-75634-AF350$485 / 100μlE20-75634-AF405M$485 / 100μlE20-75634-AF488$485 / 100μlE20-75634-AF514$485 / 100μlE20-75634-AF532$485 / 100μlE20-75634-AF555$485 / 100μlE20-75634-AF568$485 / 100μlE20-75634-AF405S$485 / 100μlE20-75634-AF405L$485 / 100μlE20-75634-AF546$485 / 100μlE20-75634-AF594$485 / 100μlE20-75634-AF610$485 / 100μlE20-75634-AF635$485 / 100μlE20-75634-AF647$485 / 100μlE20-75634-AF680$485 / 100μlE20-75634-AF700$485 / 100μlE20-75634-AF750$485 / 100μlE20-75634-AF790$485 / 100μlE20-75634-APC$485 / 100μlE20-75634-PE$485 / 100μlE20-75634-Cy3$485 / 100μlE20-75634-Cy5$485 / 100μlE20-75634-Cy5.5$485 / 100μlE20-75634-Cy7$485 / 100μlE20-75634-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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