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Cell Signal Transduction Research Antibodies
CD209 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight45775Da
Protein NameCD209 antigen
Human Gene Id30835
Human Swiss Prot NoQ9NNX6
SpecificityCD209 Polyclonal Antibody detects endogenous levels of CD209 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD209; CLEC4L; CD209 antigen; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-SIGN; DC-SIGN1; CD209
Observed Band(KD)45
Functionalternative products:Additional isoforms seem to exist. Several splicing events may be used independently in a modular way. Deletion of the transmembrane domain encoding exon through alternative splicing produces soluble isoforms,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,domain:The tandem repeat domain, also called neck domain, mediates oligermerization.,function:On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.,function:Pathogen-recognition receptor expressed on the sur
Subcellular Locationcytoplasm,plasma membrane,cell surface,membrane,integral component of membrane,extracellular exosome,
ExpressionPlacenta,Synovial membrane tissue,Trachea,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from CD209 antigen at AA range: 261-310
Gene NameCD209
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
BackgroundCD209 molecule(CD209) Homo sapiens This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino a
Conjugated Antibody
This product is also available conjugated. Format: E20-75633-Conjugate. Price: $485 / Size: 100μl.
E20-75633-FITC$485 / 100μlE20-75633-Biotin$485 / 100μlE20-75633-HRP$485 / 100μlE20-75633-AP$485 / 100μlE20-75633-AF350$485 / 100μlE20-75633-AF405M$485 / 100μlE20-75633-AF488$485 / 100μlE20-75633-AF514$485 / 100μlE20-75633-AF532$485 / 100μlE20-75633-AF555$485 / 100μlE20-75633-AF568$485 / 100μlE20-75633-AF405S$485 / 100μlE20-75633-AF405L$485 / 100μlE20-75633-AF546$485 / 100μlE20-75633-AF594$485 / 100μlE20-75633-AF610$485 / 100μlE20-75633-AF635$485 / 100μlE20-75633-AF647$485 / 100μlE20-75633-AF680$485 / 100μlE20-75633-AF700$485 / 100μlE20-75633-AF750$485 / 100μlE20-75633-AF790$485 / 100μlE20-75633-APC$485 / 100μlE20-75633-PE$485 / 100μlE20-75633-Cy3$485 / 100μlE20-75633-Cy5$485 / 100μlE20-75633-Cy5.5$485 / 100μlE20-75633-Cy7$485 / 100μlE20-75633-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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