Product Information
Molecular Weight21593Da
Protein NameNatural cytotoxicity triggering receptor 3
Human Gene Id259197
Human Swiss Prot NoO14931
Rat Swiss Prot NoQ8CFD9
SpecificityNKp30 Polyclonal Antibody detects endogenous levels of NKp30 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameNCR3; 1C7; LY117; Natural cytotoxicity triggering receptor 3; Activating natural killer receptor p30; Natural killer cell p30-related protein; NK-p30; NKp30; CD337
Observed Band(KD)21
Functionfunction:Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis.,polymorphism:A genetic variation in NCR3 is associated with mild malaria suceptibility [MIM:609148].,similarity:Belongs to the natural cytotoxicity receptor (NCR) family.,similarity:Contains 1 Ig-like (immunoglobulin-like) domain.,subunit:Interacts with CD3Z.,tissue specificity:Selectively expressed by all resting and activated NK cells and weakly expressed in spleen.,
Subcellular Locationplasma membrane,integral component of plasma membrane,cell-cell adherens junction,
ExpressionBlood,Lymphoid,Peripheral blood,Spleen,
Backgroundnatural cytotoxicity triggering receptor 3(NCR3) Homo sapiens The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2010],