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Cell Signal Transduction Research Antibodies
CD180 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight74165Da
Protein NameCD180 antigen
Human Gene Id4064
Human Swiss Prot NoQ99467
Mouse Gene Id17079
Mouse Swiss Prot NoQ62192
SpecificityCD180 Polyclonal Antibody detects endogenous levels of CD180 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameCD180; LY64; RP105; CD180 antigen; Lymphocyte antigen 64; Radioprotective 105 kDa protein; CD180
Observed Band(KD)75
Functiondisease:Decreased expression of LY64 has been shown in systemic lupus erythematosus (SLE). The loss of LY64 is associated with B-cell activation and increased disease activity in SLE patients.,function:May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells.,similarity:Belongs to the Toll-like receptor family.,similarity:Contains 17 LRR (leucine-rich) repeats.,subunit:Binds to MD-1.,tissue specificity:Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells.,
Subcellular Locationintegral component of plasma membrane,
ExpressionB-cell lymphoma,Liver,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from CD180 antigen at AA range: 221-270
Gene NameCD180
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
BackgroundCD180 molecule(CD180) Homo sapiens CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75629-Conjugate. Price: $485 / Size: 100μl.
E20-75629-FITC$485 / 100μlE20-75629-Biotin$485 / 100μlE20-75629-HRP$485 / 100μlE20-75629-AP$485 / 100μlE20-75629-AF350$485 / 100μlE20-75629-AF405M$485 / 100μlE20-75629-AF488$485 / 100μlE20-75629-AF514$485 / 100μlE20-75629-AF532$485 / 100μlE20-75629-AF555$485 / 100μlE20-75629-AF568$485 / 100μlE20-75629-AF405S$485 / 100μlE20-75629-AF405L$485 / 100μlE20-75629-AF546$485 / 100μlE20-75629-AF594$485 / 100μlE20-75629-AF610$485 / 100μlE20-75629-AF635$485 / 100μlE20-75629-AF647$485 / 100μlE20-75629-AF680$485 / 100μlE20-75629-AF700$485 / 100μlE20-75629-AF750$485 / 100μlE20-75629-AF790$485 / 100μlE20-75629-APC$485 / 100μlE20-75629-PE$485 / 100μlE20-75629-Cy3$485 / 100μlE20-75629-Cy5$485 / 100μlE20-75629-Cy5.5$485 / 100μlE20-75629-Cy7$485 / 100μlE20-75629-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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