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Cell Signal Transduction Research Antibodies
CD155 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight45303Da
Protein NamePoliovirus receptor
Human Gene Id5817
Human Swiss Prot NoP15151
SpecificityCD155 Polyclonal Antibody detects endogenous levels of CD155 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePVR; PVS; Poliovirus receptor; Nectin-like protein 5; NECL-5; CD155
Observed Band(KD)45
Functionfunction:Mediates NK cell adhesion and triggers NK cell effector functions. Binds two different NK cell receptors: CD96 and CD226. These interactions accumulates at the cell-cell contact site, leading to the formation of a mature immunological synapse between NK cell and target cell. This may trigger adhesion and secretion of lytic granules and IFN-gamma and activate cytoxicity of activated NK cells. May also promote NK cell-target cell modular exchange, and PVR transfer to the NK cell. This transfer is more important in some tumor cells expressing a lot of PVR, and may trigger fratricide NK cell activation, providing tumors with a mechanism of immunoevasion. Plays a role in mediating tumor cell invasion and migration. Serves as a receptor for poliovirus attachment to target cells. May play a role in axonal transport of poliovirus, by targeting virion-PVR-containing endocytic vesicles to
Subcellular Locationextracellular space,cytoplasm,plasma membrane,integral component of plasma membrane,cell-cell adherens junction,focal adhesion,cell surface,integral component of membrane,extracellular exosome,
ExpressionLiver,Pancreas,Placenta,Plasma,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PVR. AA range:81-130
Gene NamePVR
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundpoliovirus receptor(PVR) Homo sapiens The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75628-Conjugate. Price: $485 / Size: 100μl.
E20-75628-FITC$485 / 100μlE20-75628-Biotin$485 / 100μlE20-75628-HRP$485 / 100μlE20-75628-AP$485 / 100μlE20-75628-AF350$485 / 100μlE20-75628-AF405M$485 / 100μlE20-75628-AF488$485 / 100μlE20-75628-AF514$485 / 100μlE20-75628-AF532$485 / 100μlE20-75628-AF555$485 / 100μlE20-75628-AF568$485 / 100μlE20-75628-AF405S$485 / 100μlE20-75628-AF405L$485 / 100μlE20-75628-AF546$485 / 100μlE20-75628-AF594$485 / 100μlE20-75628-AF610$485 / 100μlE20-75628-AF635$485 / 100μlE20-75628-AF647$485 / 100μlE20-75628-AF680$485 / 100μlE20-75628-AF700$485 / 100μlE20-75628-AF750$485 / 100μlE20-75628-AF790$485 / 100μlE20-75628-APC$485 / 100μlE20-75628-PE$485 / 100μlE20-75628-Cy3$485 / 100μlE20-75628-Cy5$485 / 100μlE20-75628-Cy5.5$485 / 100μlE20-75628-Cy7$485 / 100μlE20-75628-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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