SIRP-α1/β1 Polyclonal Antibody

Name: SIRP-α1/β1 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75624
Price: 225 USD
Availability: InStock

E20-75624Cite ID: EN0055757Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight54967/43359Da

Protein NameTyrosine-protein phosphatase non-receptor type substrate 1/Signal-regulatory protein beta-1 isoform 3

Human Gene Id140885/10326/100653194

Human Swiss Prot NoP78324/Q5TFQ8

Mouse Gene Id19261

Rat Gene Id25528

Rat Swiss Prot NoP97710

SpecificitySIRP-α1/β1 Polyclonal Antibody detects endogenous levels of SIRP-α1/β1 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameSIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD172a; SIRPB1; Signal-regulatory protein beta-1 isoform 3; SIRP-beta-1 isoform 3

Observed Band(KD)55

Functionfunction:Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.,PTM:N-glycosylated.,PTM:Phosphorylated on tyrosine residues in response to stimulation with EGF, growth hormone, insulin and PDGF. Dephosphoryla

Subcellular Locationplasma membrane,membrane,integral component of membrane,extracellular exosome,

ExpressionBrain,Kidney,Liver,Monocyte,Placenta,Plasma,Skin,Thalar

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SIRPA/SIRPB1. AA range:281-330

Gene NameSIRPA/SIRPB1

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Backgroundsignal regulatory protein alpha(SIRPA) Homo sapiens The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternati

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75624-Conjugate. Price: $485 / Size: 100μl.

E20-75624-FITC$485 / 100μlE20-75624-Biotin$485 / 100μlE20-75624-HRP$485 / 100μlE20-75624-AP$485 / 100μlE20-75624-AF350$485 / 100μlE20-75624-AF405M$485 / 100μlE20-75624-AF488$485 / 100μlE20-75624-AF514$485 / 100μlE20-75624-AF532$485 / 100μlE20-75624-AF555$485 / 100μlE20-75624-AF568$485 / 100μlE20-75624-AF405S$485 / 100μlE20-75624-AF405L$485 / 100μlE20-75624-AF546$485 / 100μlE20-75624-AF594$485 / 100μlE20-75624-AF610$485 / 100μlE20-75624-AF635$485 / 100μlE20-75624-AF647$485 / 100μlE20-75624-AF680$485 / 100μlE20-75624-AF700$485 / 100μlE20-75624-AF750$485 / 100μlE20-75624-AF790$485 / 100μlE20-75624-APC$485 / 100μlE20-75624-PE$485 / 100μlE20-75624-Cy3$485 / 100μlE20-75624-Cy5$485 / 100μlE20-75624-Cy5.5$485 / 100μlE20-75624-Cy7$485 / 100μlE20-75624-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.