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Cell Signal Transduction Research Antibodies
CD158a Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight38505Da
Protein NameKiller cell immunoglobulin-like receptor 2DL1
Human Gene Id3802
Human Swiss Prot NoP43626
SpecificityCD158a Polyclonal Antibody detects endogenous levels of CD158a protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameKIR2DL1; CD158A; NKAT1; Killer cell immunoglobulin-like receptor 2DL1; CD158 antigen-like family member A; MHC class I NK cell receptor; Natural killer-associated transcript 1; NKAT-1; p58 natural killer cell receptor clones CL-42/47.11; p58 NK receptor CL-42/47.11; p58.1 MHC class-I-specific NK receptor; CD158a
Observed Band(KD)39
Functionfunction:Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis.,miscellaneous:PubMed:15580659, identified a chromosomal rearrangement producing a recombinant gene composed of the promoter and first exon of KIR2DL5A fused to KIR3DP1 which was originally thought to be a pseudogene. This leads to the expression in 4.5 percent of a Spanish Caucasoid population of an mRNA which may encode a chimeric protein KIR2DL5A/KIR3DP1.,similarity:Belongs to the immunoglobulin superfamily.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,tissue specificity:Expressed in peripheral blood cells.,
Subcellular Locationplasma membrane,integral component of plasma membrane,integral component of membrane,
ExpressionNatural killer cell
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human KIR2DL1. AA range:131-180
Gene NameKIR2DL1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundkiller cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 1(KIR2DL1) Homo sapiens Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the
Conjugated Antibody
This product is also available conjugated. Format: E20-75618-Conjugate. Price: $485 / Size: 100μl.
E20-75618-FITC$485 / 100μlE20-75618-Biotin$485 / 100μlE20-75618-HRP$485 / 100μlE20-75618-AP$485 / 100μlE20-75618-AF350$485 / 100μlE20-75618-AF405M$485 / 100μlE20-75618-AF488$485 / 100μlE20-75618-AF514$485 / 100μlE20-75618-AF532$485 / 100μlE20-75618-AF555$485 / 100μlE20-75618-AF568$485 / 100μlE20-75618-AF405S$485 / 100μlE20-75618-AF405L$485 / 100μlE20-75618-AF546$485 / 100μlE20-75618-AF594$485 / 100μlE20-75618-AF610$485 / 100μlE20-75618-AF635$485 / 100μlE20-75618-AF647$485 / 100μlE20-75618-AF680$485 / 100μlE20-75618-AF700$485 / 100μlE20-75618-AF750$485 / 100μlE20-75618-AF790$485 / 100μlE20-75618-APC$485 / 100μlE20-75618-PE$485 / 100μlE20-75618-Cy3$485 / 100μlE20-75618-Cy5$485 / 100μlE20-75618-Cy5.5$485 / 100μlE20-75618-Cy7$485 / 100μlE20-75618-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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