Product Information
Molecular Weight29341Da
Protein NameTumor necrosis factor receptor superfamily member 4
Human Gene Id7293
Human Swiss Prot NoP43489
Mouse Swiss Prot NoP47741
SpecificityOx40 Polyclonal Antibody detects endogenous levels of Ox40 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTNFRSF4; TXGP1L; Tumor necrosis factor receptor superfamily member 4; ACT35 antigen; OX40L receptor; TAX transcriptionally-activated glycoprotein 1 receptor; CD134
Observed Band(KD)30
Functionfunction:Receptor for TNFSF4/OX40L/GP34.,similarity:Contains 4 TNFR-Cys repeats.,subunit:Interacts with TRAF2, TRAF3 and TRAF5.,
Subcellular Locationplasma membrane,integral component of plasma membrane,cell surface,
ExpressionBrain,
BackgroundTNF receptor superfamily member 4(TNFRSF4) Homo sapiens The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008],