Product Information
Molecular Weight57147Da
Protein NameInterleukin-9 receptor
Human Gene Id3581
Human Swiss Prot NoQ01113
Mouse Swiss Prot NoQ01114
SpecificityIL-9R Polyclonal Antibody detects endogenous levels of IL-9R protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIL9R; Interleukin-9 receptor; IL-9 receptor; IL-9R; CD129
Observed Band(KD)58
Functiondomain:The box 1 motif is required for JAK interaction and/or activation.,domain:The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.,function:This is a receptor for interleukin-9.,miscellaneous:The gene encoding for this protein is located in the pseudoautosomal region 2 (PAR2) of X and Y chromosomes.,similarity:Belongs to the type I cytokine receptor family. Type 4 subfamily.,similarity:Contains 1 fibronectin type-III domain.,
Subcellular Locationextracellular region,extracellular space,integral component of plasma membrane,membrane,integral component of membrane,
ExpressionMelanoma,
Backgroundinterleukin 9 receptor(IL9R) Homo sapiens The protein encoded by this gene is a cytokine receptor that specifically mediates the biological effects of interleukin 9 (IL9). The functional IL9 receptor complex requires this protein as well as the interleukin 2 receptor, gamma (IL2RG), a common gamma subunit shared by the receptors of many different cytokines. The ligand binding of this receptor leads to the activation of various JAK kinases and STAT proteins, which connect to different biologic responses. This gene is located at the pseudoautosomal regions of X and Y chromosomes. Genetic studies suggested an association of this gene with the development of asthma. Multiple pseudogenes on chromosome 9, 10, 16, and 18 have been described. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008],