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Cell Signal Transduction Research Antibodies
IL-7R Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight51567Da
Protein NameInterleukin-7 receptor subunit alpha
Human Gene Id3575
Human Swiss Prot NoP16871
Mouse Swiss Prot NoP16872
SpecificityIL-7R Polyclonal Antibody detects endogenous levels of IL-7R protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIL7R; Interleukin-7 receptor subunit alpha; IL-7 receptor subunit alpha; IL-7R subunit alpha; IL-7R-alpha; IL-7RA; CDw127; CD127
Observed Band(KD)50
Functiondisease:A genetic variation in transmembrane domain of IL7R is associated with susceptibility to multiple sclerosis (MS) [MIM:126200]. Overtransmission of the major 'C' allele coding for Thr-244 are detected in offspring affected with multiple sclerosis. In vitro analysis of transcripts from minigenes containing either 'C' allele (Thr-244) or 'T' allele (Ile-244) shows that the 'C' allele results in an approximately two-fold increase in the skipping of exon 6, leading to increased production of a soluble form of IL7R. Thus, the multiple sclerosis associated 'C' risk allele of IL7R would probably decrease membrane-bound expression of IL7R. As this risk allele is common in the general population, some additional triggers are probably required for the development and progression of MS.,disease:Defects in IL7R are a cause of autosomal recessive severe combined immunodeficiency T-cell-negativ
Subcellular Locationextracellular region,plasma membrane,external side of plasma membrane,membrane,integral component of membrane,
ExpressionB-cell,Epithelium,Spleen,Testis,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human IL7R. AA range:141-190
Gene NameIL7R
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundinterleukin 7 receptor(IL7R) Homo sapiens The protein encoded by this gene is a receptor for interleukin 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukins 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in V(D)J recombination during lymphocyte development. Defects in this gene may be associated with severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found. [provided by RefSeq, Dec 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75605-Conjugate. Price: $485 / Size: 100μl.
E20-75605-FITC$485 / 100μlE20-75605-Biotin$485 / 100μlE20-75605-HRP$485 / 100μlE20-75605-AP$485 / 100μlE20-75605-AF350$485 / 100μlE20-75605-AF405M$485 / 100μlE20-75605-AF488$485 / 100μlE20-75605-AF514$485 / 100μlE20-75605-AF532$485 / 100μlE20-75605-AF555$485 / 100μlE20-75605-AF568$485 / 100μlE20-75605-AF405S$485 / 100μlE20-75605-AF405L$485 / 100μlE20-75605-AF546$485 / 100μlE20-75605-AF594$485 / 100μlE20-75605-AF610$485 / 100μlE20-75605-AF635$485 / 100μlE20-75605-AF647$485 / 100μlE20-75605-AF680$485 / 100μlE20-75605-AF700$485 / 100μlE20-75605-AF750$485 / 100μlE20-75605-AF790$485 / 100μlE20-75605-APC$485 / 100μlE20-75605-PE$485 / 100μlE20-75605-Cy3$485 / 100μlE20-75605-Cy5$485 / 100μlE20-75605-Cy5.5$485 / 100μlE20-75605-Cy7$485 / 100μlE20-75605-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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