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Cell Signal Transduction Research Antibodies
LIFR Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight123743Da
Protein NameLeukemia inhibitory factor receptor
Human Gene Id3977
Human Swiss Prot NoP42702
Mouse Swiss Prot NoP42703
SpecificityLIFR Polyclonal Antibody detects endogenous levels of LIFR protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameLIFR; Leukemia inhibitory factor receptor; LIF receptor; LIF-R; CD118
Observed Band(KD)120
Functiondisease:A chromosomal rearrangement involving LIFR may be a cause of salivary gland pleiomorphic adenomas (PA) [181030]. Pleiomorphic adenomas are the most common benign epithelial tumors of the salivary gland. Translocation t(5;8)(p13;q12) with PLAG1.,disease:Defects in LIFR are the cause of Stueve-Wiedemann syndrome (SWS) [MIM:601559]; also called Schwartz-Jampel syndrome type 2 or SJS2. SWS is a severe autosomal recessive condition and belongs to the group of the bent-bone dysplasias. SWS is characterized by bowing of the lower limbs, with internal cortical thickening, wide metaphyses with abnormal trabecular pattern, and camptodactyly. Additional features include feeding and swallowing difficulties, as well as respiratory distress and hyperthermic episodes, which cause death in the first months of life. The rare survivors develop progressive scoliosis, spontaneous fractures, bowing o
Subcellular Locationplasma membrane,integral component of plasma membrane,integral component of membrane,receptor complex,extracellular exosome,
ExpressionHippocampus,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human LIFR. AA range:731-780
Gene NameLIFR
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundleukemia inhibitory factor receptor alpha(LIFR) Homo sapiens This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t(5;8)(p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75604-Conjugate. Price: $485 / Size: 100μl.
E20-75604-FITC$485 / 100μlE20-75604-Biotin$485 / 100μlE20-75604-HRP$485 / 100μlE20-75604-AP$485 / 100μlE20-75604-AF350$485 / 100μlE20-75604-AF405M$485 / 100μlE20-75604-AF488$485 / 100μlE20-75604-AF514$485 / 100μlE20-75604-AF532$485 / 100μlE20-75604-AF555$485 / 100μlE20-75604-AF568$485 / 100μlE20-75604-AF405S$485 / 100μlE20-75604-AF405L$485 / 100μlE20-75604-AF546$485 / 100μlE20-75604-AF594$485 / 100μlE20-75604-AF610$485 / 100μlE20-75604-AF635$485 / 100μlE20-75604-AF647$485 / 100μlE20-75604-AF680$485 / 100μlE20-75604-AF700$485 / 100μlE20-75604-AF750$485 / 100μlE20-75604-AF790$485 / 100μlE20-75604-APC$485 / 100μlE20-75604-PE$485 / 100μlE20-75604-Cy3$485 / 100μlE20-75604-Cy5$485 / 100μlE20-75604-Cy5.5$485 / 100μlE20-75604-Cy7$485 / 100μlE20-75604-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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