Product Information
Molecular Weight57742Da
Protein NamePoliovirus receptor-related protein 2
Human Gene Id5819
Human Swiss Prot NoQ92692
Mouse Swiss Prot NoP32507
SpecificityNectin 2 Polyclonal Antibody detects endogenous levels of Nectin 2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePVRL2; HVEB; PRR2; Poliovirus receptor-related protein 2; Herpes virus entry mediator B; Herpesvirus entry mediator B; HveB; Nectin-2; CD112
Observed Band(KD)65
Functionfunction:Probable cell adhesion protein.,similarity:Belongs to the nectin family.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Receptor for alphaherpesvirus (HSV-1, HSV-2 and pseudorabies virus) entry into cells. Binds with low affinity to TIGIT.,tissue specificity:Ubiquitous.,
Subcellular Locationplasma membrane,integral component of plasma membrane,cell-cell junction,cell-cell adherens junction,zonula adherens,focal adhesion,cell surface,integral component of membrane,cell-cell contact zone,extracellular exosome,
ExpressionBrain,Epithelium,
Backgroundnectin cell adhesion molecule 2(NECTIN2) Homo sapiens This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],