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Cell Signal Transduction Research Antibodies
Nectin 1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight57158Da
Protein NamePoliovirus receptor-related protein 1
Human Gene Id5818
Human Swiss Prot NoQ15223
Mouse Gene Id58235
Mouse Swiss Prot NoQ9JKF6
SpecificityNectin 1 Polyclonal Antibody detects endogenous levels of Nectin 1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePVRL1; HVEC; PRR1; Poliovirus receptor-related protein 1; Herpes virus entry mediator C; Herpesvirus entry mediator C; HveC; Herpesvirus Ig-like receptor; HIgR; Nectin-1; CD111
Observed Band(KD)57
Functiondisease:Defects in PVRL1 are the cause of ectodermal dysplasia Margarita Island type (EDMI) [MIM:225060]; also known as Zlotogora-Ogur syndrome, cleft lip/palate-ectodermal dysplasia syndrome (CLPED1) or ectodermal dysplasia 4. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. EDMI is an autosomal recessive syndrome characterized by the association of cleft lip/palate, ectodermal dysplasia (sparse short and dry scalp hair, sparse eyebrows and eyelashes), and partial syndactyly of the fingers and/or toes. Two thirds of the patients do not manifest oral cleft but present with abnormal teeth and nails.,disease:Defects in PVRL1 are the cause of non-syndromic orofacial cleft type 7 (OFC7) [MIM:225060]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cle
Subcellular Locationextracellular region,plasma membrane,integral component of plasma membrane,adherens junction,cell-cell adherens junction,membrane,integral component of membrane,catenin complex,axon,growth cone membrane,presynaptic membrane
ExpressionBrain,Plasma,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PVRL1. AA range:81-130
Gene NamePVRL1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundnectin cell adhesion molecule 1(NECTIN1) Homo sapiens This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75602-Conjugate. Price: $485 / Size: 100μl.
E20-75602-FITC$485 / 100μlE20-75602-Biotin$485 / 100μlE20-75602-HRP$485 / 100μlE20-75602-AP$485 / 100μlE20-75602-AF350$485 / 100μlE20-75602-AF405M$485 / 100μlE20-75602-AF488$485 / 100μlE20-75602-AF514$485 / 100μlE20-75602-AF532$485 / 100μlE20-75602-AF555$485 / 100μlE20-75602-AF568$485 / 100μlE20-75602-AF405S$485 / 100μlE20-75602-AF405L$485 / 100μlE20-75602-AF546$485 / 100μlE20-75602-AF594$485 / 100μlE20-75602-AF610$485 / 100μlE20-75602-AF635$485 / 100μlE20-75602-AF647$485 / 100μlE20-75602-AF680$485 / 100μlE20-75602-AF700$485 / 100μlE20-75602-AF750$485 / 100μlE20-75602-AF790$485 / 100μlE20-75602-APC$485 / 100μlE20-75602-PE$485 / 100μlE20-75602-Cy3$485 / 100μlE20-75602-Cy5$485 / 100μlE20-75602-Cy5.5$485 / 100μlE20-75602-Cy7$485 / 100μlE20-75602-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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