Product Information
Molecular Weight30654Da
Protein NameIntercellular adhesion molecule 2
Human Gene Id3384
Human Swiss Prot NoP13598
Mouse Swiss Prot NoP35330
SpecificityICAM-2 Polyclonal Antibody detects endogenous levels of ICAM-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameICAM2; Intercellular adhesion molecule 2; ICAM-2; CD102
Observed Band(KD)30
Functionfunction:ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.,online information:ICAM-2,similarity:Belongs to the immunoglobulin superfamily. ICAM family.,similarity:Contains 2 Ig-like C2-type (immunoglobulin-like) domains.,
Subcellular Locationuropod,plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,extracellular exosome,
ExpressionAorta endothelial cell,Blood,Brain,Endothelial cell,Plasma,Spleen,
Backgroundintercellular adhesion molecule 2(ICAM2) Homo sapiens The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],