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Cell Signal Transduction Research Antibodies
CD98 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight67994Da
Protein Name4F2 cell-surface antigen heavy chain
Human Gene Id6520
Human Swiss Prot NoP08195
Mouse Gene Id17254
Mouse Swiss Prot NoP10852
Rat Gene Id50567
Rat Swiss Prot NoQ794F9
SpecificityCD98 Polyclonal Antibody detects endogenous levels of CD98 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSLC3A2; MDU1; 4F2 cell-surface antigen heavy chain; 4F2hc; 4F2 heavy chain antigen; Lymphocyte activation antigen 4F2 large subunit; CD98
Observed Band(KD)69
Functionfunction:Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such a
Subcellular Locationnucleus,cytoplasm,plasma membrane,cell-cell adherens junction,cell surface,membrane,integral component of membrane,apical plasma membrane,melanosome,extracellular exosome,
ExpressionB-cell lymphoma,Epithelium,Fibroblast,Liver,Lung,Mammary cancer,Pla
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human SLC3A2. AA range:491-540
Gene NameSLC3A2
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundsolute carrier family 3 member 2(SLC3A2) Homo sapiens This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010],
Conjugated Antibody
This product is also available conjugated. Format: E20-75599-Conjugate. Price: $485 / Size: 100μl.
E20-75599-FITC$485 / 100μlE20-75599-Biotin$485 / 100μlE20-75599-HRP$485 / 100μlE20-75599-AP$485 / 100μlE20-75599-AF350$485 / 100μlE20-75599-AF405M$485 / 100μlE20-75599-AF488$485 / 100μlE20-75599-AF514$485 / 100μlE20-75599-AF532$485 / 100μlE20-75599-AF555$485 / 100μlE20-75599-AF568$485 / 100μlE20-75599-AF405S$485 / 100μlE20-75599-AF405L$485 / 100μlE20-75599-AF546$485 / 100μlE20-75599-AF594$485 / 100μlE20-75599-AF610$485 / 100μlE20-75599-AF635$485 / 100μlE20-75599-AF647$485 / 100μlE20-75599-AF680$485 / 100μlE20-75599-AF700$485 / 100μlE20-75599-AF750$485 / 100μlE20-75599-AF790$485 / 100μlE20-75599-APC$485 / 100μlE20-75599-PE$485 / 100μlE20-75599-Cy3$485 / 100μlE20-75599-Cy5$485 / 100μlE20-75599-Cy5.5$485 / 100μlE20-75599-Cy7$485 / 100μlE20-75599-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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