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Cell Signal Transduction Research Antibodies
LIR-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight70819Da
Protein NameLeukocyte immunoglobulin-like receptor subfamily B member 1
Human Gene Id10859
Human Swiss Prot NoQ8NHL6
SpecificityLIR-1 Polyclonal Antibody detects endogenous levels of LIR-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameLILRB1; ILT2; LIR1; MIR7; Leukocyte immunoglobulin-like receptor subfamily B member 1; LIR-1; Leukocyte immunoglobulin-like receptor 1; CD85 antigen-like family member J; Immunoglobulin-like transcript 2; ILT-2; Monocyte/macrophage immunoglobulin-like receptor 7; MIR-7; CD85j
Observed Band(KD)72
Functiondomain:Contains 4 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calc
Subcellular Locationextracellular region,cytoplasm,plasma membrane,external side of plasma membrane,integral component of membrane,
ExpressionB-cell,Lymphoblast,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human LILRB1. AA range:21-70
Gene NameLILRB1
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundleukocyte immunoglobulin like receptor B1(LILRB1) Homo sapiens This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75596-Conjugate. Price: $485 / Size: 100μl.
E20-75596-FITC$485 / 100μlE20-75596-Biotin$485 / 100μlE20-75596-HRP$485 / 100μlE20-75596-AP$485 / 100μlE20-75596-AF350$485 / 100μlE20-75596-AF405M$485 / 100μlE20-75596-AF488$485 / 100μlE20-75596-AF514$485 / 100μlE20-75596-AF532$485 / 100μlE20-75596-AF555$485 / 100μlE20-75596-AF568$485 / 100μlE20-75596-AF405S$485 / 100μlE20-75596-AF405L$485 / 100μlE20-75596-AF546$485 / 100μlE20-75596-AF594$485 / 100μlE20-75596-AF610$485 / 100μlE20-75596-AF635$485 / 100μlE20-75596-AF647$485 / 100μlE20-75596-AF680$485 / 100μlE20-75596-AF700$485 / 100μlE20-75596-AF750$485 / 100μlE20-75596-AF790$485 / 100μlE20-75596-APC$485 / 100μlE20-75596-PE$485 / 100μlE20-75596-Cy3$485 / 100μlE20-75596-Cy5$485 / 100μlE20-75596-Cy5.5$485 / 100μlE20-75596-Cy7$485 / 100μlE20-75596-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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