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Cell Signal Transduction Research Antibodies
CD85d Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight65115Da
Protein NameLeukocyte immunoglobulin-like receptor subfamily B member 2
Human Gene Id10288
Human Swiss Prot NoQ8N423
SpecificityCD85d Polyclonal Antibody detects endogenous levels of CD85d protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameLILRB2; ILT4; LIR2; MIR10; Leukocyte immunoglobulin-like receptor subfamily B member 2; LIR-2; Leukocyte immunoglobulin-like receptor 2; CD85 antigen-like family member D; Immunoglobulin-like transcript 4; ILT-4; Monocyte/macrophage immunoglobulin-like receptor 10; MIR-10; CD85d
Observed Band(KD)66
Functiondomain:Contains 3 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions.,PTM:Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6.,similarity:Contains 4 Ig-like C2-type (immunoglobulin-like) domains.,subunit:Binds PTPN6 when phosphorylated. Binds FCGR1A.,tissue specificity:Expressed on monocytes and B-cells, a
Subcellular Locationextracellular space,cytoplasm,plasma membrane,integral component of plasma membrane,cell surface,membrane,integral component of membrane,
ExpressionDendritic cell,Peripheral blood leukocyte,Peripheral blood
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human LILRB2. AA range:121-170
Gene NameLILRB2
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundleukocyte immunoglobulin like receptor B2(LILRB2) Homo sapiens This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75595-Conjugate. Price: $485 / Size: 100μl.
E20-75595-FITC$485 / 100μlE20-75595-Biotin$485 / 100μlE20-75595-HRP$485 / 100μlE20-75595-AP$485 / 100μlE20-75595-AF350$485 / 100μlE20-75595-AF405M$485 / 100μlE20-75595-AF488$485 / 100μlE20-75595-AF514$485 / 100μlE20-75595-AF532$485 / 100μlE20-75595-AF555$485 / 100μlE20-75595-AF568$485 / 100μlE20-75595-AF405S$485 / 100μlE20-75595-AF405L$485 / 100μlE20-75595-AF546$485 / 100μlE20-75595-AF594$485 / 100μlE20-75595-AF610$485 / 100μlE20-75595-AF635$485 / 100μlE20-75595-AF647$485 / 100μlE20-75595-AF680$485 / 100μlE20-75595-AF700$485 / 100μlE20-75595-AF750$485 / 100μlE20-75595-AF790$485 / 100μlE20-75595-APC$485 / 100μlE20-75595-PE$485 / 100μlE20-75595-Cy3$485 / 100μlE20-75595-Cy5$485 / 100μlE20-75595-Cy5.5$485 / 100μlE20-75595-Cy7$485 / 100μlE20-75595-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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