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Cell Signal Transduction Research Antibodies
P-Selectin Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight91300Da
Protein NameP-selectin
Human Gene Id6403
Human Swiss Prot NoP16109
Mouse Gene Id20344
Mouse Swiss Prot NoQ01102
Rat Gene Id25651
Rat Swiss Prot NoP98106
SpecificityP-Selectin Polyclonal Antibody detects endogenous levels of P-Selectin protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSELP; GMRP; GRMP; P-selectin; CD62 antigen-like family member P; Granule membrane protein 140; GMP-140; Leukocyte-endothelial cell adhesion molecule 3; LECAM3; Platelet activation dependent granule-external membrane protein; PADGEM; CD62P
Observed Band(KD)91
Functiondisease:Defects in SELP may be a cause of susceptibility to ischemic stroke [MIM:601367]; also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.,function:Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with PSGL1.,online informati
Subcellular Locationextracellular space,nucleoplasm,cytoplasm,plasma membrane,integral component of plasma membrane,external side of plasma membrane,membrane,integral component of membrane,platelet dense granule membrane,platelet alpha granule membrane,
ExpressionBlood,Placenta,Platelet,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human SELP. AA range:81-130
Gene NameSELP
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundselectin P(SELP) Homo sapiens This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75593-Conjugate. Price: $485 / Size: 100μl.
E20-75593-FITC$485 / 100μlE20-75593-Biotin$485 / 100μlE20-75593-HRP$485 / 100μlE20-75593-AP$485 / 100μlE20-75593-AF350$485 / 100μlE20-75593-AF405M$485 / 100μlE20-75593-AF488$485 / 100μlE20-75593-AF514$485 / 100μlE20-75593-AF532$485 / 100μlE20-75593-AF555$485 / 100μlE20-75593-AF568$485 / 100μlE20-75593-AF405S$485 / 100μlE20-75593-AF405L$485 / 100μlE20-75593-AF546$485 / 100μlE20-75593-AF594$485 / 100μlE20-75593-AF610$485 / 100μlE20-75593-AF635$485 / 100μlE20-75593-AF647$485 / 100μlE20-75593-AF680$485 / 100μlE20-75593-AF700$485 / 100μlE20-75593-AF750$485 / 100μlE20-75593-AF790$485 / 100μlE20-75593-APC$485 / 100μlE20-75593-PE$485 / 100μlE20-75593-Cy3$485 / 100μlE20-75593-Cy5$485 / 100μlE20-75593-Cy5.5$485 / 100μlE20-75593-Cy7$485 / 100μlE20-75593-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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