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Cell Signal Transduction Research Antibodies
Integrin β3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight87214Da
Protein NameIntegrin beta-3
Human Gene Id3690
Human Swiss Prot NoP05106
Mouse Swiss Prot NoO54890
SpecificityIntegrin β3 Polyclonal Antibody detects endogenous levels of Integrin β3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameITGB3; GP3A; Integrin beta-3; Platelet membrane glycoprotein IIIa; GPIIIa; CD61
Observed Band(KD)87
Functiondisease:Defects in ITGB3 are a cause of Glanzmann thrombasthenia (GT) [MIM:273800]; also known as thrombasthenia of Glanzmann and Naegeli. GT is the most common inherited disease of platelets. Its inheritance is autosomal recessive. It is characterized by mucocutaneous bleeding of mild-to-moderate severity and the inability of this integrin to recognize macromolecular or synthetic peptide ligands. GT has been classified clinically into types I and II. In type I, platelets show absence of the glycoprotein IIb-IIIa complexes at their surface and lack fibrinogen and clot retraction capability. In type II, the platelets express the GPIIb-IIIa complex at reduced levels (5-20% controls), have detectable amounts of fibrinogen, and have low or moderate clot retraction capability. The platelets of GT variants have normal or near normal (60-100%) expression of dysfunctional receptors.,function:Int
Subcellular Locationnucleus,plasma membrane,integral component of plasma membrane,focal adhesion,integrin complex,cell surface,integral component of membrane,platelet alpha granule membrane,lamellipodium membrane,filopodium membrane,microvillus membrane,
ExpressionBlood,Erythroleukemia,Keratinocyte,Liver,Osteoclastoma
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human ITGB3. AA range:621-670
Gene NameITGB3
DilutionWB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300
Backgroundintegrin subunit beta 3(ITGB3) Homo sapiens The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75592-Conjugate. Price: $485 / Size: 100μl.
E20-75592-FITC$485 / 100μlE20-75592-Biotin$485 / 100μlE20-75592-HRP$485 / 100μlE20-75592-AP$485 / 100μlE20-75592-AF350$485 / 100μlE20-75592-AF405M$485 / 100μlE20-75592-AF488$485 / 100μlE20-75592-AF514$485 / 100μlE20-75592-AF532$485 / 100μlE20-75592-AF555$485 / 100μlE20-75592-AF568$485 / 100μlE20-75592-AF405S$485 / 100μlE20-75592-AF405L$485 / 100μlE20-75592-AF546$485 / 100μlE20-75592-AF594$485 / 100μlE20-75592-AF610$485 / 100μlE20-75592-AF635$485 / 100μlE20-75592-AF647$485 / 100μlE20-75592-AF680$485 / 100μlE20-75592-AF700$485 / 100μlE20-75592-AF750$485 / 100μlE20-75592-AF790$485 / 100μlE20-75592-APC$485 / 100μlE20-75592-PE$485 / 100μlE20-75592-Cy3$485 / 100μlE20-75592-Cy5$485 / 100μlE20-75592-Cy5.5$485 / 100μlE20-75592-Cy7$485 / 100μlE20-75592-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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