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Cell Signal Transduction Research Antibodies
Integrin α6 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight126619Da
Protein NameIntegrin alpha-6
Human Gene Id3655
Human Swiss Prot NoP23229
Mouse Swiss Prot NoQ61739
SpecificityIntegrin α6 Polyclonal Antibody detects endogenous levels of Integrin α6 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD49f
Observed Band(KD)125
Functionalternative products:Additional isoforms seem to exist. There is a combination of at least four alternatively spliced domains, two extracellular (X1 and X2) and two cytoplasmic (A and B). So far detected are isoform Alpha-6X1A, isoform Alpha-6X1B and isoform Alpha-6X1X2A (minor). Experimental confirmation may be lacking for some isoforms,disease:Defects in ITGA6 are a cause of epidermolysis bullosa with pyloric atresia (EB-PA) [MIM:226730]; also known as aplasia cutis congenita with gastrointestinal atresia. EB-PA is an autosomal recessive disease characterized by mucocutaneous fragility and gastrointestinal atresia, which most commonly affects the pylorus.,function:Integrin alpha-6/beta-1 is a receptor for laminin on platelets. Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome.,PTM:Isoforms containing segme
Subcellular Locationbasement membrane,plasma membrane,cell-cell adherens junction,focal adhesion,integrin complex,external side of plasma membrane,basal plasma membrane,cell surface,integral component of membrane,hemidesmosome,filopodium,integrin a
ExpressionAmygdala,Brain,Keratinocyte,Leukocyte,Liver,Lymphoma
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ITGA6. AA range:901-950
Gene NameITGA6
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundintegrin subunit alpha 6(ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75590-Conjugate. Price: $485 / Size: 100μl.
E20-75590-FITC$485 / 100μlE20-75590-Biotin$485 / 100μlE20-75590-HRP$485 / 100μlE20-75590-AP$485 / 100μlE20-75590-AF350$485 / 100μlE20-75590-AF405M$485 / 100μlE20-75590-AF488$485 / 100μlE20-75590-AF514$485 / 100μlE20-75590-AF532$485 / 100μlE20-75590-AF555$485 / 100μlE20-75590-AF568$485 / 100μlE20-75590-AF405S$485 / 100μlE20-75590-AF405L$485 / 100μlE20-75590-AF546$485 / 100μlE20-75590-AF594$485 / 100μlE20-75590-AF610$485 / 100μlE20-75590-AF635$485 / 100μlE20-75590-AF647$485 / 100μlE20-75590-AF680$485 / 100μlE20-75590-AF700$485 / 100μlE20-75590-AF750$485 / 100μlE20-75590-AF790$485 / 100μlE20-75590-APC$485 / 100μlE20-75590-PE$485 / 100μlE20-75590-Cy3$485 / 100μlE20-75590-Cy5$485 / 100μlE20-75590-Cy5.5$485 / 100μlE20-75590-Cy7$485 / 100μlE20-75590-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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