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Cell Signal Transduction Research Antibodies
Integrin α5 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight114536Da
Protein NameIntegrin alpha-5
Human Gene Id3678
Human Swiss Prot NoP08648
Mouse Gene Id16402
Mouse Swiss Prot NoP11688
SpecificityIntegrin α5 Polyclonal Antibody detects endogenous levels of Integrin α5 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e
Observed Band(KD)115
Functionfunction:Integrin alpha-5/beta-1 is a receptor for fibronectin and fibrinogen. It recognizes the sequence R-G-D in its ligands. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 7 FG-GAP repeats.,subunit:Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of an heavy and a light chain linked by a disulfide bond. Alpha-5 associates with beta-1. Interacts with HPS5 and NISCH. Interacts with HIV-1 Tat. Interacts with RAB21.,
Subcellular Locationruffle,endoplasmic reticulum,Golgi apparatus,plasma membrane,cell-cell junction,focal adhesion,integrin complex,external side of plasma membrane,cell surface,integral component of membrane,cytoplasmic vesicle,ruffle membrane,
ExpressionLiver,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ITGA5. AA range:561-610
Gene NameITGA5
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundintegrin subunit alpha 5(ITGA5) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],
Conjugated Antibody
This product is also available conjugated. Format: E20-75589-Conjugate. Price: $485 / Size: 100μl.
E20-75589-FITC$485 / 100μlE20-75589-Biotin$485 / 100μlE20-75589-HRP$485 / 100μlE20-75589-AP$485 / 100μlE20-75589-AF350$485 / 100μlE20-75589-AF405M$485 / 100μlE20-75589-AF488$485 / 100μlE20-75589-AF514$485 / 100μlE20-75589-AF532$485 / 100μlE20-75589-AF555$485 / 100μlE20-75589-AF568$485 / 100μlE20-75589-AF405S$485 / 100μlE20-75589-AF405L$485 / 100μlE20-75589-AF546$485 / 100μlE20-75589-AF594$485 / 100μlE20-75589-AF610$485 / 100μlE20-75589-AF635$485 / 100μlE20-75589-AF647$485 / 100μlE20-75589-AF680$485 / 100μlE20-75589-AF700$485 / 100μlE20-75589-AF750$485 / 100μlE20-75589-AF790$485 / 100μlE20-75589-APC$485 / 100μlE20-75589-PE$485 / 100μlE20-75589-Cy3$485 / 100μlE20-75589-Cy5$485 / 100μlE20-75589-Cy5.5$485 / 100μlE20-75589-Cy7$485 / 100μlE20-75589-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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