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Cell Signal Transduction Research Antibodies
Integrin α2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight129295Da
Protein NameIntegrin alpha-2
Human Gene Id3673
Human Swiss Prot NoP17301
Mouse Gene Id16398
Mouse Swiss Prot NoQ62469
SpecificityIntegrin α2 Polyclonal Antibody detects endogenous levels of Integrin α2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameITGA2; CD49B; Integrin alpha-2; CD49 antigen-like family member B; Collagen receptor; Platelet membrane glycoprotein Ia; GPIa; VLA-2 subunit alpha; CD49b
Observed Band(KD)130
Functiondomain:The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.,function:Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.,polymorphism:Position 534 is associated with platelet-specific alloantigen HPA-5 (Br). HPA-5A/Br(a) has Lys-534 and HPA-5B/Br(b) has Glu-534. HPA-5B is involved in neonatal alloimmune thrombocytopenia (NAIT or NATP). The Lys-534-Glu polymorphism may play a role in coronary artery disease (CAD).,similarity:Belongs to the integrin alpha chain family.,similarity:Contains 1 VWFA domai
Subcellular Locationnucleus,plasma membrane,focal adhesion,integrin complex,external side of plasma membrane,cell surface,integrin alpha2-beta1 complex,axon terminus,basal part of cell,perinuclear region of cytoplasm,
ExpressionEndothelial cell,Liver,Platelet,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human ITGA2. AA range:1081-1130
Gene NameITGA2
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundintegrin subunit alpha 2(ITGA2) Homo sapiens This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012],
Conjugated Antibody
This product is also available conjugated. Format: E20-75588-Conjugate. Price: $485 / Size: 100μl.
E20-75588-FITC$485 / 100μlE20-75588-Biotin$485 / 100μlE20-75588-HRP$485 / 100μlE20-75588-AP$485 / 100μlE20-75588-AF350$485 / 100μlE20-75588-AF405M$485 / 100μlE20-75588-AF488$485 / 100μlE20-75588-AF514$485 / 100μlE20-75588-AF532$485 / 100μlE20-75588-AF555$485 / 100μlE20-75588-AF568$485 / 100μlE20-75588-AF405S$485 / 100μlE20-75588-AF405L$485 / 100μlE20-75588-AF546$485 / 100μlE20-75588-AF594$485 / 100μlE20-75588-AF610$485 / 100μlE20-75588-AF635$485 / 100μlE20-75588-AF647$485 / 100μlE20-75588-AF680$485 / 100μlE20-75588-AF700$485 / 100μlE20-75588-AF750$485 / 100μlE20-75588-AF790$485 / 100μlE20-75588-APC$485 / 100μlE20-75588-PE$485 / 100μlE20-75588-Cy3$485 / 100μlE20-75588-Cy5$485 / 100μlE20-75588-Cy5.5$485 / 100μlE20-75588-Cy7$485 / 100μlE20-75588-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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