CD33 Polyclonal Antibody

Name: CD33 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75584
Price: 225 USD
Availability: InStock

E20-75584Cite ID: EN0055717Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight40040Da

Protein NameMyeloid cell surface antigen CD33

Human Gene Id945

Human Swiss Prot NoP20138

Mouse Swiss Prot NoQ63994

SpecificityCD33 Polyclonal Antibody detects endogenous levels of CD33 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameCD33; SIGLEC3; Myeloid cell surface antigen CD33; Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD33

Observed Band(KD)40

Functiondomain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).,online information:Siglec

Subcellular Locationplasma membrane,integral component of plasma membrane,external side of plasma membrane,integral component of membrane,extracellular exosome,

ExpressionLeukocyte,Peripheral blood,Premonocytic lymphoma,Spleen,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CD33. AA range:71-120

Gene NameCD33

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Backgrounddomain:Contains 2 copies of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.,function:Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).,online information:Siglec-3,PTM:Phosphorylation of Tyr-340 is involved in binding to PTPN6 and PTPN11. Phosphorylation of Tyr-358 is involved in binding to PTPN6.,similarity:Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.,similarity:Contains 1 Ig-like C2-type (immunoglobulin-like) domain.,similarity:Contains 1 Ig-like V-type (immunoglobulin-like) domain.,subunit:Interacts with PTPN6/SHP-1 and PTPN11/SHP-2 upon phosphorylation.,tissue specificity:Monocytic/myeloid lineage cells.,

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75584-Conjugate. Price: $485 / Size: 100μl.

E20-75584-FITC$485 / 100μlE20-75584-Biotin$485 / 100μlE20-75584-HRP$485 / 100μlE20-75584-AP$485 / 100μlE20-75584-AF350$485 / 100μlE20-75584-AF405M$485 / 100μlE20-75584-AF488$485 / 100μlE20-75584-AF514$485 / 100μlE20-75584-AF532$485 / 100μlE20-75584-AF555$485 / 100μlE20-75584-AF568$485 / 100μlE20-75584-AF405S$485 / 100μlE20-75584-AF405L$485 / 100μlE20-75584-AF546$485 / 100μlE20-75584-AF594$485 / 100μlE20-75584-AF610$485 / 100μlE20-75584-AF635$485 / 100μlE20-75584-AF647$485 / 100μlE20-75584-AF680$485 / 100μlE20-75584-AF700$485 / 100μlE20-75584-AF750$485 / 100μlE20-75584-AF790$485 / 100μlE20-75584-APC$485 / 100μlE20-75584-PE$485 / 100μlE20-75584-Cy3$485 / 100μlE20-75584-Cy5$485 / 100μlE20-75584-Cy5.5$485 / 100μlE20-75584-Cy7$485 / 100μlE20-75584-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.