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Cell Signal Transduction Research Antibodies
CD13 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight109540Da
Protein NameAminopeptidase N
Human Gene Id290
Human Swiss Prot NoP15144
Mouse Swiss Prot NoP97449
SpecificityCD13 Polyclonal Antibody detects endogenous levels of CD13 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameANPEP; APN; CD13; PEPN; Aminopeptidase N; AP-N; hAPN; Alanyl aminopeptidase; Aminopeptidase M; AP-M; Microsomal aminopeptidase; Myeloid plasma membrane glycoprotein CD13; gp150; CD13
Observed Band(KD)110
Functioncatalytic activity:Release of an N-terminal amino acid, Xaa-|-Yaa- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide.,cofactor:Binds 1 zinc ion per subunit.,disease:Defects in ANPEP may be a cause of various types of leukemia or lymphoma.,domain:Amino acids 260-353 are essential to mediate susceptibility to infection with HCoV-229E (in porcine/human chimeric studies) and more specifically amino acids 288-295 (mutagenesis studies).,function:Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabol
Subcellular Locationextracellular space,lysosomal membrane,endoplasmic reticulum-Golgi intermediate compartment,cytosol,integral component of plasma membrane,external side of plasma membrane,integral component of membrane,extracellular exosome,
ExpressionAorta endothelial cell,Bile,Epithelium,Intestinal epithelium,Intestine,Live
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenSynthesized peptide derived from Aminopeptidase N at AA range: 881-930
Gene NameANPEP
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundalanyl aminopeptidase, membrane(ANPEP) Homo sapiens Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is
Conjugated Antibody
This product is also available conjugated. Format: E20-75579-Conjugate. Price: $485 / Size: 100μl.
E20-75579-FITC$485 / 100μlE20-75579-Biotin$485 / 100μlE20-75579-HRP$485 / 100μlE20-75579-AP$485 / 100μlE20-75579-AF350$485 / 100μlE20-75579-AF405M$485 / 100μlE20-75579-AF488$485 / 100μlE20-75579-AF514$485 / 100μlE20-75579-AF532$485 / 100μlE20-75579-AF555$485 / 100μlE20-75579-AF568$485 / 100μlE20-75579-AF405S$485 / 100μlE20-75579-AF405L$485 / 100μlE20-75579-AF546$485 / 100μlE20-75579-AF594$485 / 100μlE20-75579-AF610$485 / 100μlE20-75579-AF635$485 / 100μlE20-75579-AF647$485 / 100μlE20-75579-AF680$485 / 100μlE20-75579-AF700$485 / 100μlE20-75579-AF750$485 / 100μlE20-75579-AF790$485 / 100μlE20-75579-APC$485 / 100μlE20-75579-PE$485 / 100μlE20-75579-Cy3$485 / 100μlE20-75579-Cy5$485 / 100μlE20-75579-Cy5.5$485 / 100μlE20-75579-Cy7$485 / 100μlE20-75579-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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