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Cell Signal Transduction Research Antibodies
Talin-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight279510Da
Protein NameTalin-1
Human Gene Id7094
Human Swiss Prot NoQ9Y490
Mouse Gene Id21894
Mouse Swiss Prot NoP26039
SpecificityTalin-1 Polyclonal Antibody detects endogenous levels of Talin-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameTLN1; KIAA1027; TLN; Talin-1
Observed Band(KD)269
Functionfunction:Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.,similarity:Contains 1 FERM domain.,similarity:Contains 1 I/LWEQ domain.,subcellular location:Colocalizes with LAYN at the membrane ruffles.,subunit:Binds with high affinity to vinculin and with low affinity to integrins. Interacts with PIP5K1C and NRAP. Interacts with LAYN. Interacts with SYNM.,
Subcellular Locationruffle,extracellular region,cytoplasm,microtubule organizing center,cytosol,plasma membrane,cell-cell junction,cell-cell adherens junction,focal adhesion,cell surface,ruffle membrane,extracellular exosome,
ExpressionAorta,Brain,Embryonic carcinoma,Platelet,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human TLN1. AA range:2471-2520
Gene NameTLN1
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundtalin 1(TLN1) Homo sapiens This gene encodes a cytoskeletal protein that is concentrated in areas of cell-substratum and cell-cell contacts. The encoded protein plays a significant role in the assembly of actin filaments and in spreading and migration of various cell types, including fibroblasts and osteoclasts. It codistributes with integrins in the cell surface membrane in order to assist in the attachment of adherent cells to extracellular matrices and of lymphocytes to other cells. The N-terminus of this protein contains elements for localization to cell-extracellular matrix junctions. The C-terminus contains binding sites for proteins such as beta-1-integrin, actin, and vinculin. [provided by RefSeq, Feb 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75576-Conjugate. Price: $485 / Size: 100μl.
E20-75576-FITC$485 / 100μlE20-75576-Biotin$485 / 100μlE20-75576-HRP$485 / 100μlE20-75576-AP$485 / 100μlE20-75576-AF350$485 / 100μlE20-75576-AF405M$485 / 100μlE20-75576-AF488$485 / 100μlE20-75576-AF514$485 / 100μlE20-75576-AF532$485 / 100μlE20-75576-AF555$485 / 100μlE20-75576-AF568$485 / 100μlE20-75576-AF405S$485 / 100μlE20-75576-AF405L$485 / 100μlE20-75576-AF546$485 / 100μlE20-75576-AF594$485 / 100μlE20-75576-AF610$485 / 100μlE20-75576-AF635$485 / 100μlE20-75576-AF647$485 / 100μlE20-75576-AF680$485 / 100μlE20-75576-AF700$485 / 100μlE20-75576-AF750$485 / 100μlE20-75576-AF790$485 / 100μlE20-75576-APC$485 / 100μlE20-75576-PE$485 / 100μlE20-75576-Cy3$485 / 100μlE20-75576-Cy5$485 / 100μlE20-75576-Cy5.5$485 / 100μlE20-75576-Cy7$485 / 100μlE20-75576-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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