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Cell Signal Transduction Research Antibodies
SOD-2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight24420Da
Protein NameSuperoxide dismutase [Mn] mitochondrial
Human Gene Id6648
Human Swiss Prot NoP04179
Mouse Gene Id20656
Mouse Swiss Prot NoP09671
Rat Gene Id24787
Rat Swiss Prot NoP07895
SpecificitySOD-2 Polyclonal Antibody detects endogenous levels of SOD-2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSOD2; Superoxide dismutase [Mn], mitochondrial
Observed Band(KD)24
Functioncatalytic activity:2 superoxide + 2 H(+) = O(2) + H(2)O(2).,cofactor:Binds 1 manganese ion per subunit.,disease:Genetic variation in SOD2 is associated with susceptibility to diabetic nephropathy [MIM:612634]; also called susceptibility to microvascular complications of diabetes type 6 (MVCD6). Diabetic nephropathy is a kidney disease and resultant kidney function impairment due to the long standing effects of diabetes on the microvasculature (glomerulus) of the kidney. Features include increased urine protein and declining kidney function.,function:Destroys radicals which are normally produced within the cells and which are toxic to biological systems.,online information:Superoxide dismutase entry,online information:The Singapore human mutation and polymorphism database,PTM:Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.,similarity:Belo
Subcellular Locationmitochondrion,mitochondrial inner membrane,mitochondrial matrix,mitochondrial nucleoid,myelin sheath,extracellular exosome,
ExpressionBrain,Colon,Heart,Liver,Lung,Mammary carcinoma,Tongue,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SOD2. AA range:91-140
Gene NameSOD2
DilutionIHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundsuperoxide dismutase 2, mitochondrial(SOD2) Homo sapiens This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 1. [provided by RefSeq, Apr 2016],
Conjugated Antibody
This product is also available conjugated. Format: E20-75575-Conjugate. Price: $485 / Size: 100μl.
E20-75575-FITC$485 / 100μlE20-75575-Biotin$485 / 100μlE20-75575-HRP$485 / 100μlE20-75575-AP$485 / 100μlE20-75575-AF350$485 / 100μlE20-75575-AF405M$485 / 100μlE20-75575-AF488$485 / 100μlE20-75575-AF514$485 / 100μlE20-75575-AF532$485 / 100μlE20-75575-AF555$485 / 100μlE20-75575-AF568$485 / 100μlE20-75575-AF405S$485 / 100μlE20-75575-AF405L$485 / 100μlE20-75575-AF546$485 / 100μlE20-75575-AF594$485 / 100μlE20-75575-AF610$485 / 100μlE20-75575-AF635$485 / 100μlE20-75575-AF647$485 / 100μlE20-75575-AF680$485 / 100μlE20-75575-AF700$485 / 100μlE20-75575-AF750$485 / 100μlE20-75575-AF790$485 / 100μlE20-75575-APC$485 / 100μlE20-75575-PE$485 / 100μlE20-75575-Cy3$485 / 100μlE20-75575-Cy5$485 / 100μlE20-75575-Cy5.5$485 / 100μlE20-75575-Cy7$485 / 100μlE20-75575-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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