World supplier of antibodies, antigens and kits since 2007
Cell Signal Transduction Research Antibodies
GHR Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight71500Da
Protein NameGrowth hormone receptor
Human Gene Id2690
Human Swiss Prot NoP10912
Mouse Gene Id14600
Mouse Swiss Prot NoP16882
Rat Gene Id25235
Rat Swiss Prot NoP16310
SpecificityGHR Polyclonal Antibody detects endogenous levels of GHR protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameGHR; Growth hormone receptor; GH receptor; Somatotropin receptor
Observed Band(KD)70
Functiondisease:Defects in GHR are a cause of Laron dwarfism [MIM:262500]; also known as pituitary dwarfism II; Laron-type pituitary dwarfism I (LTD1) or Laron syndrome (LS). It is the most severe form of growth hormone insensitivity (GHI) characterized by growth impairment, dysmorphic facial features and truncal obesity. Levels of GHBP are low or undetectable in patients with Laron syndrome.,disease:Defects in GHR may be a cause of short stature [MIM:604271]. Short stature is defined by a subnormal rate of growth.,domain:The box 1 motif is required for JAK interaction and/or activation.,domain:The extracellular domain is the ligand-binding domain representing the growth hormone-binding protein (GHBP).,domain:The ubiquitination-dependent endocytosis motif (UbE) is required for recruitment of the ubiquitin conjugation system on to the receptor and for its internalization.,domain:The WSXWS motif a
Subcellular Locationextracellular region,extracellular space,intracellular,nucleus,mitochondrion,plasma membrane,integral component of plasma membrane,cell surface,integral component of membrane,neuronal cell body,receptor complex,growth hormone re
ExpressionLiver,Placenta,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human GHR. AA range:21-70
Gene NameGHR
DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Backgroundgrowth hormone receptor(GHR) Homo sapiens This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75573-Conjugate. Price: $485 / Size: 100μl.
E20-75573-FITC$485 / 100μlE20-75573-Biotin$485 / 100μlE20-75573-HRP$485 / 100μlE20-75573-AP$485 / 100μlE20-75573-AF350$485 / 100μlE20-75573-AF405M$485 / 100μlE20-75573-AF488$485 / 100μlE20-75573-AF514$485 / 100μlE20-75573-AF532$485 / 100μlE20-75573-AF555$485 / 100μlE20-75573-AF568$485 / 100μlE20-75573-AF405S$485 / 100μlE20-75573-AF405L$485 / 100μlE20-75573-AF546$485 / 100μlE20-75573-AF594$485 / 100μlE20-75573-AF610$485 / 100μlE20-75573-AF635$485 / 100μlE20-75573-AF647$485 / 100μlE20-75573-AF680$485 / 100μlE20-75573-AF700$485 / 100μlE20-75573-AF750$485 / 100μlE20-75573-AF790$485 / 100μlE20-75573-APC$485 / 100μlE20-75573-PE$485 / 100μlE20-75573-Cy3$485 / 100μlE20-75573-Cy5$485 / 100μlE20-75573-Cy5.5$485 / 100μlE20-75573-Cy7$485 / 100μlE20-75573-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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