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Cell Signal Transduction Research Antibodies
PSGL-1 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight43201Da
Protein NameP-selectin glycoprotein ligand 1
Human Gene Id6404
Human Swiss Prot NoQ14242
Mouse Swiss Prot NoQ62170
SpecificityPSGL-1 Polyclonal Antibody detects endogenous levels of PSGL-1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameSELPLG; P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand; CD162
Observed Band(KD)45
Functionfunction:A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture.,online information:P-selectin glycoprotein ligand 1 entry,PTM:Displays complex, core-2, sialylated and fucosylated O-linked oligosaccharides, at least some of which appear to contain poly-N-acetyllactosamine with varying degrees of substitution. Mainly disialylated or neutral forms of the core-2 tetrasaccharide, Galbeta1-->4GlcNAcbeta1-->6(Galbeta1-->3)GalNAcOH. The GlcN:GalN ratio is approximately 2:1 and the Man:Fuc ratio 3:5. Contains about 14% fucose with alpha-1,3 linkage present in two forms: One species is a disialylated, monofucosylated glycan, and the other, a monosialylated, trifucosylated glycan with a poly
Subcellular Locationuropod,plasma membrane,integral component of plasma membrane,membrane,integral component of membrane,
ExpressionBrain,Neutrophil,Placenta,Uterus,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human SELPLG. AA range:1-50
Gene NameSELPLG
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundselectin P ligand(SELPLG) Homo sapiens This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011],
Conjugated Antibody
This product is also available conjugated. Format: E20-75572-Conjugate. Price: $485 / Size: 100μl.
E20-75572-FITC$485 / 100μlE20-75572-Biotin$485 / 100μlE20-75572-HRP$485 / 100μlE20-75572-AP$485 / 100μlE20-75572-AF350$485 / 100μlE20-75572-AF405M$485 / 100μlE20-75572-AF488$485 / 100μlE20-75572-AF514$485 / 100μlE20-75572-AF532$485 / 100μlE20-75572-AF555$485 / 100μlE20-75572-AF568$485 / 100μlE20-75572-AF405S$485 / 100μlE20-75572-AF405L$485 / 100μlE20-75572-AF546$485 / 100μlE20-75572-AF594$485 / 100μlE20-75572-AF610$485 / 100μlE20-75572-AF635$485 / 100μlE20-75572-AF647$485 / 100μlE20-75572-AF680$485 / 100μlE20-75572-AF700$485 / 100μlE20-75572-AF750$485 / 100μlE20-75572-AF790$485 / 100μlE20-75572-APC$485 / 100μlE20-75572-PE$485 / 100μlE20-75572-Cy3$485 / 100μlE20-75572-Cy5$485 / 100μlE20-75572-Cy5.5$485 / 100μlE20-75572-Cy7$485 / 100μlE20-75572-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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