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Cell Signal Transduction Research Antibodies
PPP1R15B Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight78430Da
Protein NameProtein phosphatase 1 regulatory subunit 15B
Human Gene Id84919
Human Swiss Prot NoQ5SWA1
Mouse Swiss Prot NoQ8BFW3
SpecificityPPP1R15B Polyclonal Antibody detects endogenous levels of PPP1R15B protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NamePPP1R15B; Protein phosphatase 1 regulatory subunit 15B
Observed Band(KD)78
Functionfunction:Maintains low levels of EIF2S1 phosphorylation in unstressed cells by promoting its dephosphorylation by PP1.,miscellaneous:The phosphatase activity of the PPP1R15B-PP1 complex toward EIF2S1 is specifically inhibited by Salubrinal, a drug that protects cells from endoplasmic reticulum stress.,similarity:Belongs to the PPP1R15 family.,subunit:Part of a complex containing PPP1R15B, PP1 and NCK1/2 (By similarity). Interacts with PP1.,
Subcellular Locationprotein phosphatase type 1 complex,
ExpressionEye,Liver,Stomach,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human PPP1R15B. AA range:411-460
Gene NamePPP1R15B
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundprotein phosphatase 1 regulatory subunit 15B(PPP1R15B) Homo sapiens This gene encodes a protein phosphatase I-interacting protein that promotes the dephosphorylation of eukaryotic translation initiation factor 2A to regulate translation under conditions of cellular stress. The transcribed messenger RNA contains two upstream open reading frames (ORFs) that repress translation of the main protein coding ORF under normal conditions, while the protein coding ORF is expressed at high levels in response to stress. Continual translation of the mRNA under conditions of eukaryotic translation initiation factor 2A inactivation is thought to create a feedback loop for reactivation of the gene during recovery from stress. In addition, it has been shown that this protein plays a role in membrane traffic that is independent of translation and that it is required for exocytosis from erythroleukemia cells. Allelic variants of this gene are associated with mi
Conjugated Antibody
This product is also available conjugated. Format: E20-75571-Conjugate. Price: $485 / Size: 100μl.
E20-75571-FITC$485 / 100μlE20-75571-Biotin$485 / 100μlE20-75571-HRP$485 / 100μlE20-75571-AP$485 / 100μlE20-75571-AF350$485 / 100μlE20-75571-AF405M$485 / 100μlE20-75571-AF488$485 / 100μlE20-75571-AF514$485 / 100μlE20-75571-AF532$485 / 100μlE20-75571-AF555$485 / 100μlE20-75571-AF568$485 / 100μlE20-75571-AF405S$485 / 100μlE20-75571-AF405L$485 / 100μlE20-75571-AF546$485 / 100μlE20-75571-AF594$485 / 100μlE20-75571-AF610$485 / 100μlE20-75571-AF635$485 / 100μlE20-75571-AF647$485 / 100μlE20-75571-AF680$485 / 100μlE20-75571-AF700$485 / 100μlE20-75571-AF750$485 / 100μlE20-75571-AF790$485 / 100μlE20-75571-APC$485 / 100μlE20-75571-PE$485 / 100μlE20-75571-Cy3$485 / 100μlE20-75571-Cy5$485 / 100μlE20-75571-Cy5.5$485 / 100μlE20-75571-Cy7$485 / 100μlE20-75571-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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