Product Information
Molecular Weight27904Da
Protein NameInsulin-like growth factor-binding protein 1
Human Gene Id3484
Human Swiss Prot NoP08833
Mouse Gene Id16006
Mouse Swiss Prot NoP47876
Rat Gene Id25685
Rat Swiss Prot NoP21743
SpecificityIGFBP1 Polyclonal Antibody detects endogenous levels of IGFBP1 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameIGFBP1; IBP1; Insulin-like growth factor-binding protein 1; IBP-1; IGF-binding protein 1; IGFBP-1; Placental protein 12; PP12
Observed Band(KD)28
Functionfunction:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.,PTM:Phosphorylated; probably by casein kinase II. Alters the affinity of the protein for IGFs.,similarity:Contains 1 IGFBP N-terminal domain.,similarity:Contains 1 thyroglobulin type-1 domain.,subunit:Binds equally well IGF1 and IGF2.,
Subcellular Locationextracellular region,extracellular space,
ExpressionAmniotic fluid,Decidua,Liver,Placenta,Skin,
Backgroundinsulin like growth factor binding protein 1(IGFBP1) Homo sapiens This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008],