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Cell Signal Transduction Research Antibodies
AID Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight23954Da
Protein NameActivation-induced cytidine deaminase
Human Gene Id57379
Human Swiss Prot NoQ9GZX7
Mouse Gene Id11628
Mouse Swiss Prot NoQ9WVE0
SpecificityAID Polyclonal Antibody detects endogenous levels of AID protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameAICDA; AID; Activation-induced cytidine deaminase; Cytidine aminohydrolase
Observed Band(KD)24
Functioncatalytic activity:Cytidine + H(2)O = uridine + NH(3).,cofactor:Zinc.,disease:Defects in AICDA are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2) [MIM:605258]. HIGM2 is characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE, resulting in a profound susceptibility to bacterial infections. HIGM2 causes the absence of Ig class switch recombination (CSR), the lack of Ig somatic hypermutations, and lymph node hyperplasia caused by the presence of giant germinal centers.,function:RNA-editing deaminase involved in somatic hypermutation, gene conversion, and class-switch recombination. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses.,online information:AICDA mutation db,similarity:Belongs to the cytidine and deoxycytidylate deaminase family.,tissue specificity:Str
Subcellular Locationexosome (RNase complex),nucleus,cytoplasm,
ExpressionB-cell,Colon cancer,Nasal mucosa,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human AICDA. AA range:81-130
Gene NameAICDA
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundactivation induced cytidine deaminase(AICDA) Homo sapiens This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009],
Conjugated Antibody
This product is also available conjugated. Format: E20-75566-Conjugate. Price: $485 / Size: 100μl.
E20-75566-FITC$485 / 100μlE20-75566-Biotin$485 / 100μlE20-75566-HRP$485 / 100μlE20-75566-AP$485 / 100μlE20-75566-AF350$485 / 100μlE20-75566-AF405M$485 / 100μlE20-75566-AF488$485 / 100μlE20-75566-AF514$485 / 100μlE20-75566-AF532$485 / 100μlE20-75566-AF555$485 / 100μlE20-75566-AF568$485 / 100μlE20-75566-AF405S$485 / 100μlE20-75566-AF405L$485 / 100μlE20-75566-AF546$485 / 100μlE20-75566-AF594$485 / 100μlE20-75566-AF610$485 / 100μlE20-75566-AF635$485 / 100μlE20-75566-AF647$485 / 100μlE20-75566-AF680$485 / 100μlE20-75566-AF700$485 / 100μlE20-75566-AF750$485 / 100μlE20-75566-AF790$485 / 100μlE20-75566-APC$485 / 100μlE20-75566-PE$485 / 100μlE20-75566-Cy3$485 / 100μlE20-75566-Cy5$485 / 100μlE20-75566-Cy5.5$485 / 100μlE20-75566-Cy7$485 / 100μlE20-75566-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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