TNAP Polyclonal Antibody

Name: TNAP Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75563
Price: 225 USD
Availability: InStock

E20-75563Cite ID: EN0055696Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (2)Documents

Product Information

Molecular Weight57305Da

Protein NameAlkaline phosphatase, tissue-nonspecific isozyme

Human Gene Id249

Human Swiss Prot NoP05186

Mouse Swiss Prot NoP09242

Rat Gene Id25586

Rat Swiss Prot NoP08289

SpecificityTNAP Polyclonal Antibody detects endogenous levels of TNAP protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameALPL; Alkaline phosphatase, tissue-nonspecific isozyme; AP-TNAP; TNSALP; Alkaline phosphatase liver/bone/kidney isozyme

Observed Band(KD)57

Functioncatalytic activity:A phosphate monoester + H(2)O = an alcohol + phosphate.,cofactor:Binds 1 magnesium ion.,cofactor:Binds 2 zinc ions.,disease:Defects in ALPL are a cause of hypophosphatasia adult type (hypophosphatasia) [MIM:146300].,disease:Defects in ALPL are a cause of hypophosphatasia childhood (hypophosphatasia) [MIM:241510].,disease:Defects in ALPL are a cause of hypophosphatasia infantile (hypophosphatasia) [MIM:241500]; an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood and adult type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto).,function:This isozyme may play a role in skeletal mi

Subcellular Locationproteinaceous extracellular matrix,extracellular space,plasma membrane,membrane,integral component of membrane,anchored component of membrane,extracellular membrane-bounded organelle,extracellular exosome,

ExpressionBrain,Cerebellum,Liver,Lymphoma,Osteosarcoma,Peripheral nerve,Semin

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human ALPL. AA range:1-50

Gene NameALPL

DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.

Backgroundalkaline phosphatase, liver/bone/kidney(ALPL) Homo sapiens This gene encodes a member of the alkaline phosphatase family of proteins. There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme may play a role in bone mineralization. Mutations in this gene have been linked to hypophosphatasia, a disorder that is characterized by hypercalcemia and skeletal defects. [prov

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75563-Conjugate. Price: $485 / Size: 100μl.

E20-75563-FITC$485 / 100μlE20-75563-Biotin$485 / 100μlE20-75563-HRP$485 / 100μlE20-75563-AP$485 / 100μlE20-75563-AF350$485 / 100μlE20-75563-AF405M$485 / 100μlE20-75563-AF488$485 / 100μlE20-75563-AF514$485 / 100μlE20-75563-AF532$485 / 100μlE20-75563-AF555$485 / 100μlE20-75563-AF568$485 / 100μlE20-75563-AF405S$485 / 100μlE20-75563-AF405L$485 / 100μlE20-75563-AF546$485 / 100μlE20-75563-AF594$485 / 100μlE20-75563-AF610$485 / 100μlE20-75563-AF635$485 / 100μlE20-75563-AF647$485 / 100μlE20-75563-AF680$485 / 100μlE20-75563-AF700$485 / 100μlE20-75563-AF750$485 / 100μlE20-75563-AF790$485 / 100μlE20-75563-APC$485 / 100μlE20-75563-PE$485 / 100μlE20-75563-Cy3$485 / 100μlE20-75563-Cy5$485 / 100μlE20-75563-Cy5.5$485 / 100μlE20-75563-Cy7$485 / 100μlE20-75563-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.