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Cell Signal Transduction Research Antibodies
ABCG2 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight72314Da
Protein NameATP-binding cassette sub-family G member 2
Human Gene Id9429
Human Swiss Prot NoQ9UNQ0
Mouse Swiss Prot NoQ7TMS5
SpecificityABCG2 Polyclonal Antibody detects endogenous levels of ABCG2 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameABCG2; ABCP; BCRP; BCRP1; MXR; ATP-binding cassette sub-family G member 2; Breast cancer resistance protein; CDw338; Mitoxantrone resistance-associated protein; Placenta-specific ATP-binding cassette transporter; CD338
Observed Band(KD)75
Functionfunction:Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.,induction:Up-regulated in brain tumors.,PTM:Glycosylation-deficient ABCG2 is normally expressed and functional.,similarity:Belongs to the ABC transporter family. ABCG (White) subfamily.,similarity:Contains 1 ABC transmembrane type-2 domain.,similarity:Contains 1 ABC transporter domain.,subunit:Monomer or homodimer; disulfide-linked.,tissue specificity:Highly expressed in placenta. Low expression in small i
Subcellular Locationnucleus,plasma membrane,integral component of membrane,mitochondrial membrane,
ExpressionBrain endothelium,Hippocampus,Mammary cance
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human ABCG2. AA range:461-510
Gene NameABCG2
DilutionIF: 1:50-200 Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
BackgroundATP binding cassette subfamily G member 2 (Junior blood group)(ABCG2) Homo sapiens The membrane-associated protein encoded by this gene is included in the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. Alternatively referred to as a breast cancer resistance protein, this protein functions as a xenobiotic transporter which may play a major role in multi-drug resistance. It likely serves as a cellular defense mechanism in response to mitoxantrone and anthracycline exposure. Significant expression of this protein has been observed in the placenta, which may suggest a potential role for this molecule in placenta tissue. Multiple transcript variants encoding different isoforms have been found for this gene.
Conjugated Antibody
This product is also available conjugated. Format: E20-75558-Conjugate. Price: $485 / Size: 100μl.
E20-75558-FITC$485 / 100μlE20-75558-Biotin$485 / 100μlE20-75558-HRP$485 / 100μlE20-75558-AP$485 / 100μlE20-75558-AF350$485 / 100μlE20-75558-AF405M$485 / 100μlE20-75558-AF488$485 / 100μlE20-75558-AF514$485 / 100μlE20-75558-AF532$485 / 100μlE20-75558-AF555$485 / 100μlE20-75558-AF568$485 / 100μlE20-75558-AF405S$485 / 100μlE20-75558-AF405L$485 / 100μlE20-75558-AF546$485 / 100μlE20-75558-AF594$485 / 100μlE20-75558-AF610$485 / 100μlE20-75558-AF635$485 / 100μlE20-75558-AF647$485 / 100μlE20-75558-AF680$485 / 100μlE20-75558-AF700$485 / 100μlE20-75558-AF750$485 / 100μlE20-75558-AF790$485 / 100μlE20-75558-APC$485 / 100μlE20-75558-PE$485 / 100μlE20-75558-Cy3$485 / 100μlE20-75558-Cy5$485 / 100μlE20-75558-Cy5.5$485 / 100μlE20-75558-Cy7$485 / 100μlE20-75558-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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