AChRα1 Polyclonal Antibody

Name: AChRα1 Polyclonal Antibody
Brand: EnoGene Biotech Co. Ltd
SKU: E20-75555
Price: 225 USD
Availability: InStock

E20-75555Cite ID: EN0055688Datasheet COA MSDS

SourcePolyclonal, Rabbit

$225/ 100ul

Quantity

Total: $225

Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.

OverviewImages & Data (1)Documents

Product Information

Molecular Weight54546Da

Protein NameAcetylcholine receptor subunit alpha

Human Gene Id1134

Human Swiss Prot NoP02708

Mouse Gene Id11435

Mouse Swiss Prot NoP04756

Rat Gene Id79557

Rat Swiss Prot NoP25108

SpecificityAChRα1 Polyclonal Antibody detects endogenous levels of AChRα1 protein.

FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration1 mg/ml

Storage Stability-20°C/1 year

Other NameCHRNA1; ACHRA; CHNRA; Acetylcholine receptor subunit alpha

Observed Band(KD)55

Functiondisease:Defects in CHRNA1 are a cause of congenital myasthenic syndrome fast-channel type (FCCMS) [MIM:608930]. FCCMS is a congenital myasthenic syndrome characterized by kinetic abnormalities of the AChR. In most cases, FCCMS is due to mutations that decrease activity of the AChR by slowing the rate of opening of the receptor channel, speeding the rate of closure of the channel, or decreasing the number of openings of the channel during ACh occupancy. The result is failure to achieve threshold depolarization of the endplate and consequent failure to fire an action potential.,disease:Defects in CHRNA1 are a cause of congenital myasthenic syndrome slow-channel type (SCCMS) [MIM:601462]. SCCMS is the most common congenital myasthenic syndrome. Congenital myasthenic syndromes are characterized by muscle weakness affecting the axial and limb muscles (with hypotonia in early-onset forms), the

Subcellular Locationplasma membrane,acetylcholine-gated channel complex,cell surface,integral component of membrane,cell junction,neuromuscular junction,postsynaptic membrane,

ExpressionMuscle,Thymus,Tongue,

PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human CHRNA1. AA range:171-220

Gene NameCHRNA1

DilutionWestern Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

Backgroundcholinergic receptor nicotinic alpha 1 subunit(CHRNA1) Homo sapiens The muscle acetylcholine receptor consiststs of 5 subunits of 4 different types: 2 alpha subunits and 1 each of the beta, gamma, and delta subunits. This gene encodes an alpha subunit that plays a role in acetlycholine binding/channel gating. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Nov 2012],

📄Datasheet
Full product datasheet (PDF)✅Certificate of Analysis
Lot-specific COA (generated from product data)🧪MSDS
Material safety data sheet (generated)

Conjugated Antibody

This product is also available conjugated. Format: E20-75555-Conjugate. Price: $485 / Size: 100μl.

E20-75555-FITC$485 / 100μlE20-75555-Biotin$485 / 100μlE20-75555-HRP$485 / 100μlE20-75555-AP$485 / 100μlE20-75555-AF350$485 / 100μlE20-75555-AF405M$485 / 100μlE20-75555-AF488$485 / 100μlE20-75555-AF514$485 / 100μlE20-75555-AF532$485 / 100μlE20-75555-AF555$485 / 100μlE20-75555-AF568$485 / 100μlE20-75555-AF405S$485 / 100μlE20-75555-AF405L$485 / 100μlE20-75555-AF546$485 / 100μlE20-75555-AF594$485 / 100μlE20-75555-AF610$485 / 100μlE20-75555-AF635$485 / 100μlE20-75555-AF647$485 / 100μlE20-75555-AF680$485 / 100μlE20-75555-AF700$485 / 100μlE20-75555-AF750$485 / 100μlE20-75555-AF790$485 / 100μlE20-75555-APC$485 / 100μlE20-75555-PE$485 / 100μlE20-75555-Cy3$485 / 100μlE20-75555-Cy5$485 / 100μlE20-75555-Cy5.5$485 / 100μlE20-75555-Cy7$485 / 100μlE20-75555-PE-Cy5$485 / 100μl

Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.