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Cell Signal Transduction Research Antibodies
ApoC-III Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight10852Da
Protein NameApolipoprotein C-III
Human Gene Id345
Human Swiss Prot NoP02656
Mouse Swiss Prot NoP33622
SpecificityApoC-III Polyclonal Antibody detects endogenous levels of ApoC-III protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameAPOC3; Apolipoprotein C-III; Apo-CIII; ApoC-III; Apolipoprotein C3
Observed Band(KD)11
Functiondisease:Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).,function:Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.,PTM:O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues.,similarity:Belongs to the apolipoprotein C3 family.,tissue specificity:Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.,
Subcellular Locationextracellular region,extracellular space,early endosome,very-low-density lipoprotein particle,intermediate-density lipoprotein particle,spherical high-density lipoprotein particle,chylomicron,extracellular exosome,
ExpressionPancreas,PCR rescued clones,Spleen,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human APOC3. AA range:46-95
Gene NameAPOC3
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundapolipoprotein C3(APOC3) Homo sapiens Apolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75550-Conjugate. Price: $485 / Size: 100μl.
E20-75550-FITC$485 / 100μlE20-75550-Biotin$485 / 100μlE20-75550-HRP$485 / 100μlE20-75550-AP$485 / 100μlE20-75550-AF350$485 / 100μlE20-75550-AF405M$485 / 100μlE20-75550-AF488$485 / 100μlE20-75550-AF514$485 / 100μlE20-75550-AF532$485 / 100μlE20-75550-AF555$485 / 100μlE20-75550-AF568$485 / 100μlE20-75550-AF405S$485 / 100μlE20-75550-AF405L$485 / 100μlE20-75550-AF546$485 / 100μlE20-75550-AF594$485 / 100μlE20-75550-AF610$485 / 100μlE20-75550-AF635$485 / 100μlE20-75550-AF647$485 / 100μlE20-75550-AF680$485 / 100μlE20-75550-AF700$485 / 100μlE20-75550-AF750$485 / 100μlE20-75550-AF790$485 / 100μlE20-75550-APC$485 / 100μlE20-75550-PE$485 / 100μlE20-75550-Cy3$485 / 100μlE20-75550-Cy5$485 / 100μlE20-75550-Cy5.5$485 / 100μlE20-75550-Cy7$485 / 100μlE20-75550-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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