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Cell Signal Transduction Research Antibodies
Bag-3 Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight61595Da
Protein NameBAG family molecular chaperone regulator 3
Human Gene Id9531
Human Swiss Prot NoO95817
Mouse Swiss Prot NoQ9JLV1
SpecificityBag-3 Polyclonal Antibody detects endogenous levels of Bag-3 protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameBAG3; BIS; BAG family molecular chaperone regulator 3; BAG-3; Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1
Observed Band(KD)80
Functionfunction:Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Has anti-apoptotic activity.,similarity:Contains 1 BAG domain.,similarity:Contains 2 WW domains.,subunit:Binds to the ATPase domain of HSP70/HSC chaperones. Binds to Bcl-2 and PLC-gamma.,
Subcellular Locationcytoplasm,cytosol,plasma membrane,cell-cell adherens junction,Z disc,neuron projection,
ExpressionBrain,Epithelium,Liver,Lung,Placenta,T-cell,Testis,Tongue,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human BAG3. AA range:311-360
Gene NameBAG3
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
BackgroundBCL2 associated athanogene 3(BAG3) Homo sapiens BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008],
Conjugated Antibody
This product is also available conjugated. Format: E20-75544-Conjugate. Price: $485 / Size: 100μl.
E20-75544-FITC$485 / 100μlE20-75544-Biotin$485 / 100μlE20-75544-HRP$485 / 100μlE20-75544-AP$485 / 100μlE20-75544-AF350$485 / 100μlE20-75544-AF405M$485 / 100μlE20-75544-AF488$485 / 100μlE20-75544-AF514$485 / 100μlE20-75544-AF532$485 / 100μlE20-75544-AF555$485 / 100μlE20-75544-AF568$485 / 100μlE20-75544-AF405S$485 / 100μlE20-75544-AF405L$485 / 100μlE20-75544-AF546$485 / 100μlE20-75544-AF594$485 / 100μlE20-75544-AF610$485 / 100μlE20-75544-AF635$485 / 100μlE20-75544-AF647$485 / 100μlE20-75544-AF680$485 / 100μlE20-75544-AF700$485 / 100μlE20-75544-AF750$485 / 100μlE20-75544-AF790$485 / 100μlE20-75544-APC$485 / 100μlE20-75544-PE$485 / 100μlE20-75544-Cy3$485 / 100μlE20-75544-Cy5$485 / 100μlE20-75544-Cy5.5$485 / 100μlE20-75544-Cy7$485 / 100μlE20-75544-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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