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Cell Signal Transduction Research Antibodies
ANG I Polyclonal Antibody
Polyclonal, Rabbit
$225/ 100ul
QuantityTotal: $225
Ship worldwide. Contact order@enogene.com for ordering and bulk pricing or contact your local distributor.
Product Information
Molecular Weight16550Da
Protein NameAngiogenin
Human Gene Id283
Human Swiss Prot NoP03950
Mouse Swiss Prot NoP21570
SpecificityANG I Polyclonal Antibody detects endogenous levels of ANG I protein.
FormulationLiquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration1 mg/ml
Storage Stability-20°C/1 year
Other NameANG; RNASE5; Angiogenin; Ribonuclease 5; RNase 5
Observed Band(KD)17
Functioncaution:It is uncertain whether Met-1 or Met-3 is the initiator.,developmental stage:Low level expression in the developing fetus, increased in the neonate, and maximal in the adult.,disease:Defects in ANG are the cause of susceptibility to amyotrophic lateral sclerosis type 9 (ALS9) [MIM:611895]. ALS is a degenerative disorder of motor neurons in the cortex, brain stem and spinal cord. ALS is characterized by muscular weakness and atrophy.,function:May function as a tRNA-specific ribonuclease that binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus, thereby promoting the endothelial invasiveness necessary for blood vessel formation. Angiogenin induces vascularization of normal and malignant tissues. Abolishes protein synthesis by specifically hydrolyzing cellular tRNAs.,online information:Angiogenin,similarity:Belongs
Subcellular Locationextracellular region,basal lamina,extracellular space,nucleus,nucleolus,cytoplasmic, membrane-bounded vesicle,growth cone,cytoplasmic vesicle,angiogenin-PRI complex,neuronal cell body,extracellular exosome,
ExpressionLiver,Small intestine,
PurificationThe antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human ANG. AA range:11-60
Gene NameANG
DilutionWestern Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Backgroundangiogenin(ANG) Homo sapiens The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. In addition, the mature peptide has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Aug 2014],
Conjugated Antibody
This product is also available conjugated. Format: E20-75543-Conjugate. Price: $485 / Size: 100μl.
E20-75543-FITC$485 / 100μlE20-75543-Biotin$485 / 100μlE20-75543-HRP$485 / 100μlE20-75543-AP$485 / 100μlE20-75543-AF350$485 / 100μlE20-75543-AF405M$485 / 100μlE20-75543-AF488$485 / 100μlE20-75543-AF514$485 / 100μlE20-75543-AF532$485 / 100μlE20-75543-AF555$485 / 100μlE20-75543-AF568$485 / 100μlE20-75543-AF405S$485 / 100μlE20-75543-AF405L$485 / 100μlE20-75543-AF546$485 / 100μlE20-75543-AF594$485 / 100μlE20-75543-AF610$485 / 100μlE20-75543-AF635$485 / 100μlE20-75543-AF647$485 / 100μlE20-75543-AF680$485 / 100μlE20-75543-AF700$485 / 100μlE20-75543-AF750$485 / 100μlE20-75543-AF790$485 / 100μlE20-75543-APC$485 / 100μlE20-75543-PE$485 / 100μlE20-75543-Cy3$485 / 100μlE20-75543-Cy5$485 / 100μlE20-75543-Cy5.5$485 / 100μlE20-75543-Cy7$485 / 100μlE20-75543-PE-Cy5$485 / 100μl
Contact order@enogene.com to order conjugated formats. Magnetic Beads (1-30μm) conjugation is also available.
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